Diabetes and the brain: oxidative stress, inflammation, and autophagy
Ver/ Abrir
Impacto
Scholar |
Otros documentos de la autoría: Muriach Saurí, María; Flores-Bellver, Miguel; Romero, Francisco J.; Barcia, Jorge M
Metadatos
Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
comunitat-uji-handle4:
INVESTIGACIONMetadatos
Título
Diabetes and the brain: oxidative stress, inflammation, and autophagyFecha de publicación
2014Editor
Hindawi Publishing CorporationTipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.hindawi.com/journals/omcl/2014/102158/Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate
cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not ... [+]
Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate
cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not attributable to other causes, and shares
many symptoms that are best described as accelerated brain ageing. A common theory for aging and for the pathogenesis of this
cerebral dysfunctioning in diabetes relates cell death to oxidative stress in strong association to inflammation, and in fact nuclear
factor kB (NFkB), a master regulator of inflammation and also a sensor of oxidative stress, has a strategic position at the crossroad
between oxidative stress and inflammation. Moreover, metabolic inflammation is, in turn, related to the induction of various
intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect. In parallel,
blockade of autophagy can relate to proinflammatory signaling via oxidative stress pathway and NFkB-mediated inflammation. [-]
Publicado en
Oxidative Medicine and Cellular Longevity, Volume 2014, Article ID 102158Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- MED_Articles [637]
El ítem tiene asociados los siguientes ficheros de licencia:
Excepto si se señala otra cosa, la licencia del ítem se describe como: Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.