Listar por tema "Inflammation"

Mostrando ítems 1-7 de 7

    • openAccess   Defective Induction of COX-2 Expression by Psoriatic Fibroblasts Promotes Pro-inflammatory Activation of Macrophages 

      Arasa, Jorge; Terencio, M. Carmen; Andrés, Rosa M.; Marín Castejón, María Asunción; Valcuende-Cavero, Francisca; Payá, Miguel; Montesinos, M. Carmen Frontiers Media (2019-03-20)
      Fibroblasts play an important role as members of the innate immune system through the secretion of COX-2-derived inflammatory mediators such as prostaglandin E2 (PGE2). However, it has been described that dermal fibroblasts ...

    • openAccess   Diabetes and the brain: oxidative stress, inflammation, and autophagy 

      Muriach Saurí, María; Flores-Bellver, Miguel; Romero, Francisco J.; Barcia, Jorge M Hindawi Publishing Corporation (2014)
      Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not ...

    • openAccess   IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease 

      Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Gómez, Aurora; Ros Bernal, Francisco; Aguado Yera, D.; Martínez Pagán, M. E.; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2011)
      To through light on the mechanisms underlying the stimulation and persistence of glial cell activation in Parkinsonism, we investigate the function of IFN-c and TNF-a in experimental models of Parkinson’s disease and ...

    • closedAccess   Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques 

      Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013-08)
      Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ...

    • openAccess   Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques 

      Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013)
      Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ...

    • openAccess   Protein adsorption and macrophage polarization as biocompatibility markers for biomaterial design 

      Araujo da Cunha Gomes, Nuno Miguel Universitat Jaume I (2019-01-15)
      The standard protocol before proceeding to clinical trials of a biomaterial is to follow a battery of determined in vitro following in vivo experimentation. The lack of correlation between in vitro and in vivo experimentation ...

    • openAccess   ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo 

      Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Ros Bernal, Francisco; Gómez, Aurora; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2012)
      The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental ...