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Diabetes and the brain: oxidative stress, inflammation, and autophagy
dc.contributor.author | Muriach Saurí, María | |
dc.contributor.author | Flores-Bellver, Miguel | |
dc.contributor.author | Romero, Francisco J. | |
dc.contributor.author | Barcia, Jorge M | |
dc.date.accessioned | 2015-05-13T18:17:08Z | |
dc.date.available | 2015-05-13T18:17:08Z | |
dc.date.issued | 2014 | |
dc.identifier.uri | http://hdl.handle.net/10234/120507 | |
dc.description.abstract | Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not attributable to other causes, and shares many symptoms that are best described as accelerated brain ageing. A common theory for aging and for the pathogenesis of this cerebral dysfunctioning in diabetes relates cell death to oxidative stress in strong association to inflammation, and in fact nuclear factor kB (NFkB), a master regulator of inflammation and also a sensor of oxidative stress, has a strategic position at the crossroad between oxidative stress and inflammation. Moreover, metabolic inflammation is, in turn, related to the induction of various intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect. In parallel, blockade of autophagy can relate to proinflammatory signaling via oxidative stress pathway and NFkB-mediated inflammation. | ca_CA |
dc.format.extent | 10 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Hindawi Publishing Corporation | ca_CA |
dc.relation.isPartOf | Oxidative Medicine and Cellular Longevity, Volume 2014, Article ID 102158 | ca_CA |
dc.rights | Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | ca_CA |
dc.rights | Attribution 4.0 Spain | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | Diabetes | ca_CA |
dc.subject | Brain | ca_CA |
dc.subject | Oxidative Stress | ca_CA |
dc.subject | Inflammation | ca_CA |
dc.subject | Autophagy | ca_CA |
dc.title | Diabetes and the brain: oxidative stress, inflammation, and autophagy | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | http://dx.doi.org/10.1155/2014/102158 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | http://www.hindawi.com/journals/omcl/2014/102158/ | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion |
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Excepto si se señala otra cosa, la licencia del ítem se describe como: Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.