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dc.contributor.authorMuriach Saurí, María
dc.contributor.authorFlores-Bellver, Miguel
dc.contributor.authorRomero, Francisco J.
dc.contributor.authorBarcia, Jorge M.
dc.date.accessioned2015-05-13T18:17:08Z
dc.date.available2015-05-13T18:17:08Z
dc.date.issued2014
dc.identifier.urihttp://hdl.handle.net/10234/120507
dc.description.abstractDiabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not attributable to other causes, and shares many symptoms that are best described as accelerated brain ageing. A common theory for aging and for the pathogenesis of this cerebral dysfunctioning in diabetes relates cell death to oxidative stress in strong association to inflammation, and in fact nuclear factor kB (NFkB), a master regulator of inflammation and also a sensor of oxidative stress, has a strategic position at the crossroad between oxidative stress and inflammation. Moreover, metabolic inflammation is, in turn, related to the induction of various intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect. In parallel, blockade of autophagy can relate to proinflammatory signaling via oxidative stress pathway and NFkB-mediated inflammation.ca_CA
dc.format.extent10 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherHindawi Publishing Corporationca_CA
dc.relation.isPartOfOxidative Medicine and Cellular Longevity, Volume 2014, Article ID 102158ca_CA
dc.rightsCopyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.ca_CA
dc.rightsAttribution 3.0 Spain*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/*
dc.subjectDiabetesca_CA
dc.subjectBrainca_CA
dc.subjectOxidative Stressca_CA
dc.subjectInflammationca_CA
dc.subjectAutophagyca_CA
dc.titleDiabetes and the brain: oxidative stress, inflammation, and autophagyca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1155/2014/102158
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessca_CA
dc.relation.publisherVersionhttp://www.hindawi.com/journals/omcl/2014/102158/ca_CA


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Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Except where otherwise noted, this item's license is described as Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.