2024-03-29T09:01:03Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1205072021-06-10T18:04:19Zcom_10234_36080com_10234_9col_10234_36082
Repositori UJI
author
Muriach Saurí, María
author
Flores-Bellver, Miguel
author
Romero, Francisco J.
author
Barcia, Jorge M
2015-05-13T18:17:08Z
2015-05-13T18:17:08Z
2014
http://hdl.handle.net/10234/120507
http://dx.doi.org/10.1155/2014/102158
Diabetes mellitus is a common metabolic disorder associated with chronic complications including a state of mild to moderate
cognitive impairment, in particular psychomotor slowing and reduced mental flexibility, not attributable to other causes, and shares
many symptoms that are best described as accelerated brain ageing. A common theory for aging and for the pathogenesis of this
cerebral dysfunctioning in diabetes relates cell death to oxidative stress in strong association to inflammation, and in fact nuclear
factor kB (NFkB), a master regulator of inflammation and also a sensor of oxidative stress, has a strategic position at the crossroad
between oxidative stress and inflammation. Moreover, metabolic inflammation is, in turn, related to the induction of various
intracellular stresses such as mitochondrial oxidative stress, endoplasmic reticulum (ER) stress, and autophagy defect. In parallel,
blockade of autophagy can relate to proinflammatory signaling via oxidative stress pathway and NFkB-mediated inflammation.
eng
Copyright © 2014 María Muriach et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Attribution 4.0 Spain
Diabetes
Brain
Oxidative Stress
Inflammation
Autophagy
Diabetes and the brain: oxidative stress, inflammation, and autophagy
info:eu-repo/semantics/article
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