Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
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Other documents of the author: Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad
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comunitat-uji-handle2:10234/36080
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http://dx.doi.org/10.1016/j.jneuroim.2013.05.001 |
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Title
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaquesAuthor (s)
Date
2013-08Publisher
ElsevierBibliographic citation
BARCIA, Carlos, et al. Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques. Journal of neuroimmunology, 2013, 261.1: 60-66.Type
info:eu-repo/semantics/articlePublisher version
http://www.sciencedirect.com/science/article/pii/S0165572813001331Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still ... [+]
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process. [-]
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Journal of Neuroimmunology Volume 261, Issues 1–2, 15 August 2013Rights
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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- MED_Articles [673]