Listar por autoría "5d909716-66f3-4c42-a0a0-becb8d36c980"
Mostrando ítems 1-20 de 21
-
7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease
Yuste Jiménez, José Enrique; Echeverry, M. B.; Ros Bernal, Francisco; Gómez, Aurora; Ros Gómez, Carmen María; Campuzano Brando, Carmen María; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2012)Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular messenger systems in the brain. Nitric Oxide (NO) contributes to inducing signaling cascades that involve a complex pattern of ... -
Alpha-Theta effects associated with ageing during the stroop test
Nombela, Cristina; Nombela, Manuel; Castell, Pedro; García, Teodoro; López Coronado, Juan; Herrero Ezquerro, María Trinidad Public Library of Science (2014)The Stroop effect is considered as a standard attentional measure to study conflict resolution in humans. The response of the brain to conflict is supposed to change over time and it is impaired in certain pathological ... -
Alterations in energy metabolism, neuroprotection and visual signal transduction in the retina of parkinsonian, MPTP-treated monkeys
Campello, Laura; Esteve Rudd, Julián; Bru Martínez, Roque; Herrero Ezquerro, María Trinidad; Fernández Villalba, Emiliano; Cuenca, Nicolás; Martín Nieto, José Public Library of Science (2013)Campello L, Esteve-Rudd J, Bru-Martínez R, Herrero MT, Fernández-Villalba E, et al. (2013) Alterations in Energy Metabolism, Neuroprotection and Visual Signal Transduction in the Retina of Parkinsonian, MPTP-Treated ... -
CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo
Carrillo-de Sauvage, María Ángeles; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Martín, Eduardo D.; Pérez Vallés, Ana; Gallego Sánchez, José María; Fernández Villalba, Emiliano; Barcia Sr., Carlos; Barcia, Carlos; Herrero Ezquerro, María Trinidad Public Library of Science (2012)CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how ... -
Critical evaluation of the anatomical location of the Barrington nucleus: relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus
Herrero Ezquerro, María Trinidad; Blanco, Lisette; Yuste Jiménez, José Enrique; Carrillo de Sauvage, María Ángeles; Gómez, Aurora; Fernández Villalba, Emiliano; Avilés Olmos, Iciar; Limousin, Patricia; Zrinzo, Ludvic Elsevier (2013)Deep brain stimulation (DBS) has become the standard surgical procedure for advanced Parkinson’s disease (PD). Recently, the pedunculopontine tegmental nucleus (PPN) has emerged as a potential target for DBS in patients ... -
Dopamine modulation affects the performance of parkinsonian patients in a precision motor task measured by an antropomorphic device
Nombela, Cristina; Pedreño Molina, Juan Luis; Ros Bernal, Francisco; Molina Vilaplana, Javier; Fernández Villalba, Emiliano; López Coronado, Juan; Herrero Ezquerro, María Trinidad Elsevier (2012)Several parameters related to the timing, grip force and load force involved in a precision grasping task were studied in patients with Parkinson’s disease (PD) at different moments of medication and healthy controls, using ... -
Effects of pharmacological agents, sleep deprivation, hypoxia and transcranial magnetic stimulation on electroencephalographic rhythms in rodents: Towards translational challenge models for drug discovery in Alzheimer’s disease
Babiloni, Claudio; Infarinato, Francesco; Aujard, Fabienne; Bastlund, Jesper Frank; Bentivoglio, Marina; Bertini, Giuseppe; Del Percio, Claudio; Fabene, Paolo Francesco; Forloni, GianLuigi; Herrero Ezquerro, María Trinidad; Noè, Francesco Mattia; Pifferi, Fabien; Ros Bernal, Francisco; Christensen, Ditte Zerlang; Dix, Sophie; Richardson, Jill C.; Lamberty, Yves; Drinkenburg, Wilhelmus; Rossini, Paolo Maria Elsevier (2013)Different kinds of challenge can alter spontaneous ongoing electroencephalographic (EEG) rhythms in animal models, thus providing paradigms to evaluate treatment effects in drug discovery. The effects of challenges represented ... -
Evaluation of symptomatic drug effects in Alzheimer’s disease: strategies for prediction of efficacy in humans
Deguil, J.; Ravasi, L.; Auffret, A.; Babiloni, Claudio; Bartrés Faz, David; Bragulat, V.; Cassé-Perro, C.; Colavito, V.; Herrero Ezquerro, María Trinidad; Lamberty, Yves; Lanteaume, L.; Pemberton, D.; Pifferi, Fabien; Richardson, Jill C.; Schenker, Esther; Blin, Olivier; Tarragon Cros, Ernesto; Bordet, Regis Elsevier (2013)In chronic diseases such as Alzheimer's disease (AD), the arsenal of biomarkers available to determine the effectiveness of symptomatic treatment is very limited. Interpretation of the results provided in literature is ... -
Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
Annese, Valentina; Barcia, Carlos; Ros Bernal, Francisco; Gómez, Aurora; Ros Gómez, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; De Stefano, Maria Egle; Herrero Ezquerro, María Trinidad Wiley (2013)Aims: Mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) represent elective experimental models of Parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway ... -
Functional role of Barrington’s nucleus in the micturition reflex: Relevance in the surgical treatment of Parkinson’s disease
Herrero Ezquerro, María Trinidad; Blanco, Lisette; Ros Gómez, Carmen María; Tarragon Cros, Ernesto; Fernández Villalba, Emiliano Elsevier (2014)The pontine micturition center or Barrington’s nucleus (BN) – besides regulating micturition – co-regulates the activity of other pelvic viscera such as the colon and genitals. At present, this issue is gaining particular ... -
IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease
Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Gómez, Aurora; Ros Bernal, Francisco; Aguado Yera, D.; Martínez Pagán, M. E.; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2011)To through light on the mechanisms underlying the stimulation and persistence of glial cell activation in Parkinsonism, we investigate the function of IFN-c and TNF-a in experimental models of Parkinson’s disease and ... -
Memantine prevents reference and working memory impairment caused by sleep deprivation in both young and aged Octodon degus
Herrero Ezquerro, María Trinidad; Tarragon Cros, Ernesto; López, Dolores; Estrada, Cristina; González Cuello, Ana; Ros Gómez, Carmen María; Lamberty, Yves; Pifferi, Fabien; Cella, Massimo; Canovi, Mara; Guiso, Giovanna; Gobbi, Marco; Fernández Villalba, Emiliano; Blin, Olivier; Bordet, Regis; Richardson, Jill C. Elsevier (2014-10)Memory loss is one of the key features of cognitive impairment in either aging, Mild Cognitive Impairment (MCI) or dementia. Pharmacological treatments for memory loss are today focused on addressing symptomatology. One ... -
Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
Annese, Valentina; Herrero Ezquerro, María Trinidad; Di Pentima, M.; Gómez, Aurora; Lombardi, L.; Ros Gómez, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; De Stefano, Maria Egle Springer (2014-02)Inflammation is a predominant aspect of neurodegenerative diseases, manifested by glia activation and expression of pro-inflammatory mediators. Studies on animal models of Parkinson’s disease (PD) suggest that sustained ... -
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
Heman, Paola; Barcia, Carlos; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Yuste Jiménez, José Enrique; De Pablos, Vicente; Fernández Villalba, Emiliano; Toledo-Cárdenas, María Rebeca; Herrero Ezquerro, María Trinidad Universidad de Murcia (2012)In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic ... -
Octodon degus: A Model for the Cognitive Impairment Associated with Alzheimer's Disease
Tarragon Cros, Ernesto; López, Dolores; Estrada, Cristina; Schenker, Esther; Bordet, Regis; Richardson, Jill C.; Herrero Ezquerro, María Trinidad; González Cuello, Ana Wiley (2013-05-27)Octodon degus (O. degus) is a diurnal rodent that spontaneously develops several physiopathological conditions, analogous in many cases to those experienced by humans. In light of this, O. degus has recently been identified ... -
Parkinson’s disease and autophagy
Sánchez-Pérez, Ana María; Claramonte Clausell, Berta; Sanchez-Andres, Juan V.; Herrero Ezquerro, María Trinidad Hindawi Publishing Corporation (2012)It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result ... -
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013-08)Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ... -
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013)Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ... -
Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation
Carrillo de Sauvage, María Ángeles; Maatouk, L.; Arnoux, I.; Pasco, M.; Sanz Díez, A.; Delahaye, M.; Herrero Ezquerro, María Trinidad; Newman, T.A.; Calvo, C.F.; Audinat, E.; Tronche, F.; Vyas, S. Nature Publishing Group (2013-09)In CNS, glucocorticoids (GCs) activate both GC receptor (GR) and mineralocorticoid receptor (MR), whereas GR is widely expressed, the expression of MR is restricted. However, both are present in the microglia, the resident ... -
ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo
Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Ros Bernal, Francisco; Gómez, Aurora; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2012)The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental ...