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dc.contributor.authorBarcia, Carlos
dc.contributor.authorRos Gómez, Carmen María
dc.contributor.authorRos Bernal, Francisco
dc.contributor.authorGómez, Aurora
dc.contributor.authorAnnese, Valentina
dc.contributor.authorCarrillo de Sauvage, María Ángeles
dc.contributor.authorYuste Jiménez, José Enrique
dc.contributor.authorCampuzano Brando, Carmen María
dc.contributor.authorDe Pablos, Vicente
dc.contributor.authorFernández Villalba, Emiliano
dc.contributor.authorHerrero Ezquerro, María Trinidad
dc.date.accessioned2014-03-07T08:43:32Z
dc.date.available2014-03-07T08:43:32Z
dc.date.issued2013-08
dc.identifier.citationBARCIA, Carlos, et al. Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques. Journal of neuroimmunology, 2013, 261.1: 60-66.ca_CA
dc.identifier.urihttp://hdl.handle.net/10234/85869
dc.description.abstractPatients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process.ca_CA
dc.format.extent6 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherElsevierca_CA
dc.relation.isPartOfJournal of Neuroimmunology Volume 261, Issues 1–2, 15 August 2013ca_CA
dc.subjectParkinson's diseaseca_CA
dc.subjectMPTPca_CA
dc.subjectDopaminergic degenerationca_CA
dc.subjectCell polarityca_CA
dc.subjectInflammationca_CA
dc.subjectMicroglial motilityca_CA
dc.titlePersistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaquesca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1016/j.jneuroim.2013.05.001
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://www.sciencedirect.com/science/article/pii/S0165572813001331ca_CA


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