Listar por autoría "87b58bec-7712-418e-9254-c6bb5b788366"
Mostrando ítems 1-10 de 10
-
7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease
Yuste Jiménez, José Enrique; Echeverry, M. B.; Ros Bernal, Francisco; Gómez, Aurora; Ros Gómez, Carmen María; Campuzano Brando, Carmen María; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2012)Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular messenger systems in the brain. Nitric Oxide (NO) contributes to inducing signaling cascades that involve a complex pattern of ... -
CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo
Carrillo-de Sauvage, María Ángeles; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Martín, Eduardo D.; Pérez Vallés, Ana; Gallego Sánchez, José María; Fernández Villalba, Emiliano; Barcia Sr., Carlos; Barcia, Carlos; Herrero Ezquerro, María Trinidad Public Library of Science (2012)CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how ... -
Critical evaluation of the anatomical location of the Barrington nucleus: relevance for deep brain stimulation surgery of pedunculopontine tegmental nucleus
Herrero Ezquerro, María Trinidad; Blanco, Lisette; Yuste Jiménez, José Enrique; Carrillo de Sauvage, María Ángeles; Gómez, Aurora; Fernández Villalba, Emiliano; Avilés Olmos, Iciar; Limousin, Patricia; Zrinzo, Ludvic Elsevier (2013)Deep brain stimulation (DBS) has become the standard surgical procedure for advanced Parkinson’s disease (PD). Recently, the pedunculopontine tegmental nucleus (PPN) has emerged as a potential target for DBS in patients ... -
Evidence of oligodendrogliosis in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
Annese, Valentina; Barcia, Carlos; Ros Bernal, Francisco; Gómez, Aurora; Ros Gómez, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; De Stefano, Maria Egle; Herrero Ezquerro, María Trinidad Wiley (2013)Aims: Mice and nonhuman primates administered with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) represent elective experimental models of Parkinsonism, in which degeneration of the nigrostriatal dopaminergic pathway ... -
IFN-c signaling, with the synergistic contribution of TNF-a, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease
Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Gómez, Aurora; Ros Bernal, Francisco; Aguado Yera, D.; Martínez Pagán, M. E.; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2011)To through light on the mechanisms underlying the stimulation and persistence of glial cell activation in Parkinsonism, we investigate the function of IFN-c and TNF-a in experimental models of Parkinson’s disease and ... -
Metalloproteinase-9 contributes to inflammatory glia activation and nigro-striatal pathway degeneration in both mouse and monkey models of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinsonism
Annese, Valentina; Herrero Ezquerro, María Trinidad; Di Pentima, M.; Gómez, Aurora; Lombardi, L.; Ros Gómez, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; De Stefano, Maria Egle Springer (2014-02)Inflammation is a predominant aspect of neurodegenerative diseases, manifested by glia activation and expression of pro-inflammatory mediators. Studies on animal models of Parkinson’s disease (PD) suggest that sustained ... -
Nigral degeneration correlates with persistent activation of cerebellar Purkinje cells in MPTP-treated monkeys
Heman, Paola; Barcia, Carlos; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Yuste Jiménez, José Enrique; De Pablos, Vicente; Fernández Villalba, Emiliano; Toledo-Cárdenas, María Rebeca; Herrero Ezquerro, María Trinidad Universidad de Murcia (2012)In the present work we analyze the cerebellum of chronic parkinsonian monkeys in order to clarify whether chronic mesencephalic depletion is associated with long term activation of the cerebellar neurons in chronic ... -
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013-08)Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ... -
Persistent phagocytic characteristics of microglia in the substantia nigra of long-term Parkinsonian macaques
Barcia, Carlos; Ros Gómez, Carmen María; Ros Bernal, Francisco; Gómez, Aurora; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Elsevier (2013)Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, ... -
ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo
Barcia, Carlos; Ros Gómez, Carmen María; Annese, Valentina; Carrillo-de Sauvage, María Ángeles; Ros Bernal, Francisco; Gómez, Aurora; Yuste Jiménez, José Enrique; Campuzano Brando, Carmen María; De Pablos, Vicente; Fernández Villalba, Emiliano; Herrero Ezquerro, María Trinidad Nature Publishing Group (2012)The role of microglial motility in the context of adult neurodegeneration is poorly understood. In the present work, we investigated the microanatomical details of microglia-neuron interactions in an experimental ...