Spatio‐temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring
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Otros documentos de la autoría: González-Mariño, Iria; Baz Lomba, Jose Antonio; Alygizakis, Nikiforos; Andrés-Costa, Maria Jesús; Bade, Richard; Bannwarth, Anne; Barron, Leon; Been, Frederic; Benaglia, Lisa; Berset, Jean-Daniel; Bijlsma, Lubertus; Bodík, Igor; Brenner, Asher; Brock, Andreas L.; Burgard, Daniel A.; Castrignanò, Erika; Celma, Alberto; Christophoridis, Christophoros; Covaci, Adrian; Delémont, Olivier; de Voogt, Pim; Devault, Damien A.; Mário J. Dias, Mário J.; Emke, Erik; Esseiva, Pierre; Fatta-Kassinos, Despo; Fedorova, Ganna; Fytianos, Konstantinos; Gerber, Cobus; Grabic, Roman; GRACIA LOR, EMMA; Grüner, Stefan; Gunnar, Teemu; Hapeshi, Evroula; Heath, Ester; Helm, Björn; Hernandez, Felix; Kankaanpaa, Aino; Kasprzyk-Hordern, Barbara; Krizman-Matasic, Ivona; Lai, Foon Yin; Lechowicz, Wojciech; Lopes, Alvaro; López de Alda, Miren; López-García, Ester; Löve, Arndís; Mastroianni, Nicola; McEneff, Gillian; Montes, Rosa; Munro, Kelly; Nefau, Thomas; Oberacher, Herbert; O'Brien, Jake William; Oertel, Reinhard; Olafsdottir, Kristin; Picó, Yolanda; Plosz, Benedek; Polesel, Fabio; Postigo, Cristina; Quintana, José Benito; Ramin Pedram; Reid, Malcolm J.; Rice, Jack; Rodil, Rosario; Salgueiro-González, Noelia; Schubert, Sara; Senta, Ivan; Simões, Susana M.; Sremački, Maja; Styszko, Katarzyna; Terzic, Senka; Thomaidis, Nikolaos; Thomas, Kevin V.; Tscharke, Ben J.; Udrisard, Robin; van Nuijs, Alexander; Yargeau Viviane; Zuccato, Ettore; Castiglioni, Sara; Ort, Christoph
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Título
Spatio‐temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoringAutoría
Fecha de publicación
2020-01Editor
WileyISSN
0965-2140; 1360-0443Cita bibliográfica
González‐Mariño, I., Baz‐Lomba, J. A., Alygizakis, N. A., Andrés‐Costa, M. J., Bade, R., Bannwarth, A., Barron, L. P., Been, F., Benaglia, L., Berset, J.‐D., Bijlsma, L., Bodík, I., Brenner, A., Brock, A. L., Burgard, D. A., Castrignanò, E., Celma, A., Christophoridis, C. E., Covaci, A., Delémont, O., de Voogt, P., Devault, D. A., Dias, M. J., Emke, E., Esseiva, P., Fatta‐Kassinos, D., Fedorova, G., Fytianos, K., Gerber, C., Grabic, R., Gracia‐Lor, E., Grüner, S., Gunnar, T., Hapeshi, E., Heath, E., Helm, B., Hernández, F., Kankaanpaa, A., Karolak, S., Kasprzyk‐Hordern, B., Krizman‐Matasic, I., Lai, F. Y., Lechowicz, W., Lopes, A., López de Alda, M., López‐García, E., Löve, A. S. C., Mastroianni, N., McEneff, G. L., Montes, R., Munro, K., Nefau, T., Oberacher, H., O'Brien, J. W., Oertel, R., Olafsdottir, K., Picó, Y., Plósz, B. G., Polesel, F., Postigo, C., Quintana, J. B., Ramin, P., Reid, M. J., Rice, J., Rodil, R., Salgueiro‐González, N., Schubert, S., Senta, I., Simões, S. M., Sremacki, M. M., Styszko, K., Terzic, S., Thomaidis, N. S., Thomas, K. V., Tscharke, B. J., Udrisard, R., van Nuijs, A. L. N., Yargeau, V., Zuccato, E., Castiglioni, S., and Ort, C. ( 2020) Spatio‐temporal assessment of illicit drug use at large scale: evidence from 7 years of international wastewater monitoring. Addiction, 115: 109– 120. https://doi.org/10.1111/add.14767.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://onlinelibrary.wiley.com/doi/full/10.1111/add.14767Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background and aims:
Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) ... [+]
Background and aims:
Wastewater‐based epidemiology is an additional indicator of drug use that is gaining reliability to complement the current established panel of indicators. The aims of this study were to: (i) assess spatial and temporal trends of population‐normalized mass loads of benzoylecgonine, amphetamine, methamphetamine and 3,4‐methylenedioxymethamphetamine (MDMA) in raw wastewater over 7 years (2011–17); (ii) address overall drug use by estimating the average number of combined doses consumed per day in each city; and (iii) compare these with existing prevalence and seizure data.
Design:
Analysis of daily raw wastewater composite samples collected over 1 week per year from 2011 to 2017.
Setting and Participants:
Catchment areas of 143 wastewater treatment plants in 120 cities in 37 countries.
Measurements:
Parent substances (amphetamine, methamphetamine and MDMA) and the metabolites of cocaine (benzoylecgonine) and of Δ9‐tetrahydrocannabinol (11‐nor‐9‐carboxy‐Δ9‐tetrahydrocannabinol) were measured in wastewater using liquid chromatography–tandem mass spectrometry. Daily mass loads (mg/day) were normalized to catchment population (mg/1000 people/day) and converted to the number of combined doses consumed per day. Spatial differences were assessed world‐wide, and temporal trends were discerned at European level by comparing 2011–13 drug loads versus 2014–17 loads.
Findings:
Benzoylecgonine was the stimulant metabolite detected at higher loads in southern and western Europe, and amphetamine, MDMA and methamphetamine in East and North–Central Europe. In other continents, methamphetamine showed the highest levels in the United States and Australia and benzoylecgonine in South America. During the reporting period, benzoylecgonine loads increased in general across Europe, amphetamine and methamphetamine levels fluctuated and MDMA underwent an intermittent upsurge.
Conclusions:
The analysis of wastewater to quantify drug loads provides near real‐time drug use estimates that globally correspond to prevalence and seizure data. [-]
Publicado en
Addiction, 2020, vol. 115, no 1Proyecto de investigación
European Cooperation in Science and Technology. Grant Number: COST Action ES1307; European Monitoring Centre for Drugs and Drug Addiction (EMCDDA); The Icelandic Research Fund. Grant Number: 163049‐051; Wastewater Analysis of Traces of illicit drug‐related Chemicals for law enforcement and public Health (WATCH). Grant Number: HOME/2015/ISFP/PR/DRUG/0062; EU International Training Network SEWPROF. Grant Numbers: 317205, Marie Curie‐FP7‐PEOPLE; Environmental Sustainability Knowledge Transfer Network, Engineering and Physical Sciences Research Council and Thermo Fisher Scientific; Galician Council of Culture, Education and Universities. Grant Number: ED481D 2017/003; MINECO/AEI. Grant Numbers: CTM2014‐56628‐C3‐2‐R, CTM2016‐81935‐REDT, CTM2017‐84763‐C3‐2‐R, CTQ2015‐65603‐P; Slovene Research Agency. Grant Number: L1‐9191; Natural Sciences and Engineering Research Council of Canada (NSERC); Thyne Reid FoundationDerechos de acceso
http://rightsstatements.org/vocab/InC/1.0/
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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