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Is self-guided internet-based cognitive behavioural therapy (iCBT) harmful? An individual participant data meta-analysis
(Cambridge University Press, 2018)
Background. Little is known about potential harmful effects as a consequence of self-guided
internet-based cognitive behaviour therapy (iCBT), such as symptom deterioration rates.
Thus, safety concerns remain and hamper ...
Partial reversal of the effort-related motivational effects of tetrabenazinewith the MAO-B inhibitor deprenyl (selegiline): Implications for treatingmotivational dysfunctions
(Elsevier, 2018)
People with depression and Parkinsonism frequently show effort-related motivational symptoms, such as an-ergia, psychomotor retardation, and fatigue. Tasks that assess effort-related choice are being used as animalmodels of ...
Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
(Frontiers Media, 2020-01-30)
Physical activities can have intrinsic motivational or reinforcing properties. The choice
to engage in voluntary physical activity is undertaken in relation to the selection of
other alternatives, such as sedentary ...
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
(Frontiers Media, 2018-03)
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental
actions. Moreover, organisms often make ...
Assessing Future Expectations and the Two-Dimensional Model of Affect in an Italian Population
(Elsevier, 2017)
Future-directed thinking has been described as part of two underlying systems that integrate dimensions of
affect, motivational systems, orientation to the future, and future expectations, which are initiated at the
cognitive, ...
Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
(Elsevier, 2020)
Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ...
Exploring the Relationship Between the Acceptability of an InternetBased Intervention for Depression in Primary Care and Clinical Outcomes: Secondary Analysis of a Randomized Controlled Trial
(Frontiers Media, 2019-05-10)
Background: Depression is one of the most prevalent psychological disorders worldwide.
Although psychotherapy for depression is effective, there are barriers to its implementation
in primary care in Spain. The use of the ...
The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding
(Frontiers Media, 2019-06-28)
Animal studies of effort-based choice behavior are being used to model effort-related
motivational dysfunctions in humans. With these procedures, animals are offered a choice
between high-effort instrumental actions ...
The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making
(Elsevier, 2020)
Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. Nonselective adenosine antagonists such as the methylxanthine caffeine as well as selective adenosine ...
European COMPARative Effectiveness research on blended Depression treatment versus treatment-as-usual (E-COMPARED): study protocol for a randomized controlled, non-inferiority trial in eight European countries
(BioMed Central, 2016)
Background
Effective, accessible, and affordable depression treatment is of high importance considering the large personal and economic burden of depression. Internet-based treatment is considered a promising clinical ...