Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
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Otros documentos de la autoría: Salamone, John; Correa, Merce; Yang, Jen-Hau; Rotolo, Renee; Presby, Rose
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Título
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational ResearchFecha de publicación
2018-03Editor
Frontiers MediaCita bibliográfica
SALAMONE, John D.; CORREA SANZ, Mercé; YANG, Jen-Hau; ROTOLO, Renee; PRESBY, Rose. (2018). Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research. Frontiers in Behavioral Neuroscience, v. 12,Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.frontiersin.org/articles/10.3389/fnbeh.2018.00052/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental
actions. Moreover, organisms often make ... [+]
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental
actions. Moreover, organisms often make effort-related decisions involving economic
choices such as cost/benefit analyses. Effort-based decision making is studied using
behavioral procedures that offer choices between high-effort options leading to relatively
preferred reinforcers vs. low effort/low reward choices. Several neural systems, including
the mesolimbic dopamine (DA) system and other brain circuits, are involved in regulating
effort-related aspects of motivation. Considerable evidence indicates that mesolimbic
DA transmission exerts a bi-directional control over exertion of effort on instrumental
behavior tasks. Interference with DA transmission produces a low-effort bias in animals
tested on effort-based choice tasks, while increasing DA transmission with drugs such
as DA transport blockers tends to enhance selection of high-effort options. The results
from these pharmacology studies are corroborated by the findings from recent articles
using optogenetic, chemogenetic and physiological techniques. In addition to providing
important information about the neural regulation of motivated behavior, effort-based
choice tasks are useful for developing animal models of some of the motivational
symptoms that are seen in people with various psychiatric and neurological disorders
(e.g., depression, schizophrenia, Parkinson’s disease). Studies of effort-based decision
making may ultimately contribute to the development of novel drug treatments for
motivational dysfunction. [-]
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Frontiers in Behavioral Neurioscience (2018), v. 12Proyecto de investigación
Much of the work cited in this review was supported by grants to JDS from the US NIH/NIMH R03MH112984, Shire and Prexa, and to MC from PSI2015-68497-R grantDerechos de acceso
info:eu-repo/semantics/openAccess
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