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Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
(Elsevier, 2016)
Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ...
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
(Springer, 2020)
Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational
symptoms of depression and other disorders. Previous research has shown that the DA depleting ...
Expectations, experiences and attitudes of patients and primary care health professionals regarding online psychotherapeutic interventions for depression: protocol for a qualitative study
(BioMed Central, 2013-02-20)
Background: In the year 2020, depression will cause the second highest amount of disability worldwide. One quarter of the population will suffer from depression symptoms at some point in their lives. Mental health services ...
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
(Springer Verlag, 2016)
Rationale
Motivational dysfunctions such as anergia, fatigue,
and reduced effort expenditure are common in patients with
depression and other disorders. Pro-inflammatory cytokines
are implicated in depression, and ...
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
(Elsevier, 2016)
This review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts ...
Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040
(Elsevier, 2016)
Psychiatric disorders are often marked by effort-related motivational symptoms such as anergia, fatigue, psychomotor retardation, and alterations in effort-based decision making. Animal studies of effort-related choice ...
Low intensity vs. self-guided Internet-delivered psychotherapy for major depression: A multicenter, controlled, randomized study
(BioMed Central, 2013-01-11)
Background: Major depression will become the second most important cause of disability in 2020. Computerized
cognitive-behaviour therapy could be an efficacious and cost-effective option for its treatment. No studies on ...
Capturing the Severity and Impairment Associated With Depression: The Overall Depression Severity and Impairment Scale (ODSIS) Validation in a Spanish Clinical Sample
(Frontiers Media, 2019-04-09)
Background: The Overall Depression Severity and Impairment Scale (ODSIS) is a
self-report scale designed to evaluate the severity and functional impairment associated
with depression.
Objective: This study evaluated the ...
Selection of sucrose concentration depends on the effort required to obtain it: studies using tetrabenazine, D1, D2, and D3 receptor antagonists
(Springer Verlag, 2015)
Rationale Low doses of dopamine (DA) antagonists and accumbens
DA depletions reduce food-reinforced instrumental
behavior but do not impair primary food motivation, causing
animals to reallocate behavior away from ...
Intra-accumbens injections of the adenosine A(2A) agonist CGS 21680 affect effort-related choice behavior in rats
(Springer Verlag, 2008)
Rationale: Nucleus accumbens dopamine (DA) participates in the modulation of instrumental behavior,
including aspects of behavioral activation and effort-related choice behavior. Rats with impaired
accumbens DA transmission ...