Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
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Otros documentos de la autoría: Yohn, Samantha E.; Arif, Yumna; Haley, Allison; Tripodi, Guiseppe; Baqi, Younis; Müller, Christa E.; San Miguel Segura, Noemí; Correa, Merce; Salamone, John
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Título
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterizationAutoría
Fecha de publicación
2016Editor
Springer VerlagISSN
0033-3158; 1432-2072Cita bibliográfica
YOHN, Samantha E., et al. Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization. Psychopharmacology, 2016, vol. 233, no 19-20, p. 3575-3586.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://link.springer.com/article/10.1007/s00213-016-4392-9Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Rationale
Motivational dysfunctions such as anergia, fatigue,
and reduced effort expenditure are common in patients with
depression and other disorders. Pro-inflammatory cytokines
are implicated in depression, and ... [+]
Rationale
Motivational dysfunctions such as anergia, fatigue,
and reduced effort expenditure are common in patients with
depression and other disorders. Pro-inflammatory cytokines
are implicated in depression, and cytokine administration in-
duces motivational deficits in humans.
Objectives
These studies focused on the effects of the cyto-
kine interleukin-6 (IL-6) on effort-related decision-making.
Methods
Rats were assessed using the concurrent fixed ratio
5-lever pressing/chow feeding choice procedure, which mea-
sures the tendency of rats to work for a preferred food (high
carbohydrate pellets) in the presence of a concurrently avail-
able but less preferred substitute (lab chow).
Results
IL-6 (2.0
–
8.0
μ
g/kg IP) shifted choice behavior, sig-
nificantly decreasing lever pressing and increasing chow in-
take. Further experiments showed that the adenosine A
2A
an-
tagonist MSX-3 and the stimulant methylphenidate attenuated
the effort-related impairments produced by IL-6, increasing
lever pressing and decreasing chow intake in IL-6 treated rats.
The same doses of IL-6 did not alter food intake or preference
in parallel free-feeding choice studies, demonstrating that
these low doses were not altering preference for the high car-
bohydrate pellets or generally suppressing appetite. Also, IL-6 did not affect body temperature. Microdialysis studies showed
that 8.0
μ
g/kg IL-6 significantly decreased extracellular dopa-
mine in nucleus accumbens core.
Conclusions
In summary, IL-6 reduces the tendency to work
for food, even at low doses that do not produce fever or loss of
appetite. Dopaminergic mechanisms may be involved in these
effort-related effects. This research has implications for the
involvement of cytokines in motivational dysfunctions such
as anergia and fatigue. [-]
Publicado en
Psychopharmacology, 2016, vol. 233, núm. 19-20Derechos de acceso
© Springer-Verlag Berlin Heidelberg 2016. "The final publication is available at Springer via http://dx.doi.org/10.1007/s00213-016-4392-9"
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