Dopamine/adenosine interaction in effort-related processes in rodents: Studies using T-Maze paradigm in mice
comunitat-uji-handle:10234/10
comunitat-uji-handle2:10234/158177
comunitat-uji-handle3:10234/76326
comunitat-uji-handle4:10234/77866
REVISTESMetadatos
Título
Dopamine/adenosine interaction in effort-related processes in rodents: Studies using T-Maze paradigm in miceFecha de publicación
2008Editor
Universitat Jaume IISSN
1139-5486Tipo de documento
info:eu-repo/semantics/articleVersión
info:eu-repo/semantics/submittedVersionPalabras clave / Materias
Filosofía | Philosophy | Philosophie | History | Histoire | Historia | Ciències de la comunicació | Communication Sciences | Sciences de la Communication | Ciencias de la comunicación | Filología | Philologie | Philology | Traducció i Interpretació | Translation and Interpretation | Traduction et interprétation | Traducción e Interpretación
Resumen
Humans and animals realize cost/benefits analysis of our responses with the goal of use the lowest
energy possible to obtain the major benefit. Mesolimbic dopamine (DA) is a critic component in
the cerebral circuitry ... [+]
Humans and animals realize cost/benefits analysis of our responses with the goal of use the lowest
energy possible to obtain the major benefit. Mesolimbic dopamine (DA) is a critic component in
the cerebral circuitry regulating decision making based on the effort that the response requires,
because it regulates behavioral activation. Research with rodents show that DA antagonists displace
the behavior from the response that supposes more effort, though it has more reinforcement, to other
behavior with less effort required. Interaction between A2A adenosine receptors and D2 receptors
play an essential paper in these processes. In the T-Maze paradigm the animal is exposed to an
option of choose one arm with two food pellets, to which it accedes after climbing a 14 cm barrier,
or to choose the arm without barrier and with only one food pellet. Control animals choose to do the
effort of climbing the barrier to obtain the high reinforcement. Haloperidol, D2 antagonist, produces
change behavior towards the less density arm, been this effect partially reverted with theophylline,
unspecific adenosine antagonist, and with MSX-3, selective A2A antagonist. These drugs could have
applications for the treatment of amotivational syndromes. [-]
Descripción
Catorzenes Jornades de Foment de la Investigació de la FCHS (Any 2008-2009)
Publicado en
Fòrum de recerca nº 14,2008-2009Derechos de acceso
info:eu-repo/semantics/openAccess
Aparece en las colecciones
- PSB_Articles [1329]
- Fòrum de recerca 14/ 2009 [42]