Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
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Otros documentos de la autoría: Asensio, Eva Maria; Ortega-Azorín, Carolina; Barragán-Arnal, Rocío; Alvarez-Sala, Andrea; Sorlí, José V; Pascual, Eva C.; Fernández-Carrión, Rebeca; Villamil, Laura V.; Corella, Dolores; Coltell, Oscar
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Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean PopulationAutoría
Fecha de publicación
2022Editor
MDPICita bibliográfica
Asensio, E.M.; Ortega-Azorín, C.; Barragán, R.; Alvarez-Sala, A.; Sorlí, J.V.; Pascual, E.C.; Fernández-Carrión, R.; Villamil, L.V.; Corella, D.; Coltell, O. Association between MicrobiomeRelated Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population. Medicina 2022, 58, 1238. https://doi.org/ 10.3390/medicina58091238Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.mdpi.com/1648-9144/58/9/1238Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background and Objectives: The gut microbiota has been increasingly recognized as a
relevant factor associated with metabolic diseases. However, directly measuring the microbiota
composition is a limiting factor for ... [+]
Background and Objectives: The gut microbiota has been increasingly recognized as a
relevant factor associated with metabolic diseases. However, directly measuring the microbiota
composition is a limiting factor for several studies. Therefore, using genetic variables as proxies
for the microbiota composition is an important issue. Landmark microbiome–host genome-wide
association studies (mbGWAS) have identified many SNPs associated with gut microbiota. Our aim
was to analyze the association between relevant microbiome-related genetic variants (Mi-RSNPs)
and fasting glucose and type 2 diabetes in a Mediterranean population, exploring the interaction
with Mediterranean diet adherence. Materials and Methods: We performed a cross-sectional study
in a high-cardiovascular-risk Mediterranean population (n = 1020), analyzing the association of
Mi-RSNPs (from four published mbGWAS) with fasting glucose and type 2 diabetes. A single-variant
approach was used for fitting fasting glucose and type 2 diabetes to a multivariable regression
model. In addition, a Mendelian randomization analysis with multiple variants was performed as a
sub-study. Results: We obtained several associations between Mi-RSNPs and fasting plasma glucose
involving gut Gammaproteobacteria_HB, the order Rhizobiales, the genus Rumminococcus torques
group, and the genus Tyzzerella as the top ranked. For type 2 diabetes, we also detected significant
associations with Mi-RSNPs related to the order Rhizobiales, the family Desulfovibrionaceae, and the
genus Romboutsia. In addition, some Mi-RSNPs and adherence to Mediterranean diet interactions
were detected. Lastly, the formal Mendelian randomization analysis suggested combined effects.
Conclusions: Although the use of Mi-RSNPs as proxies of the microbiome is still in its infancy, and
although this is the first study analyzing such associations with fasting plasma glucose and type 2
diabetes in a Mediterranean population, some interesting associations, as well as modulations, with
adherence to the Mediterranean diet were detected in these high-cardiovascular-risk subjects, eliciting
new hypotheses. [-]
Publicado en
Medicina, 2022, 58.Entidad financiadora
Generalitat Valenciana | Instituto de Salud Carlos III | Ministerio de Economía y Competitividad | Fondo Europeo de Desarrollo Regional
Código del proyecto o subvención
PROMETEO 17/2017 | PROMETEO/2021/021 | APOSTD/2019/136 | APOSTD/2020/164 | CIBER 06/03 | SAF2016–80532-R | PID2019-108858RB-I00 | AEI 10.13039/501100011033
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