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Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population
dc.contributor.author | Asensio, Eva Maria | |
dc.contributor.author | Ortega-Azorín, Carolina | |
dc.contributor.author | Barragán-Arnal, Rocío | |
dc.contributor.author | Alvarez-Sala, Andrea | |
dc.contributor.author | Sorlí, José V | |
dc.contributor.author | Pascual, Eva C. | |
dc.contributor.author | Fernández-Carrión, Rebeca | |
dc.contributor.author | Villamil, Laura V. | |
dc.contributor.author | Corella, Dolores | |
dc.contributor.author | Coltell, Oscar | |
dc.date.accessioned | 2023-03-23T11:09:05Z | |
dc.date.available | 2023-03-23T11:09:05Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Asensio, E.M.; Ortega-Azorín, C.; Barragán, R.; Alvarez-Sala, A.; Sorlí, J.V.; Pascual, E.C.; Fernández-Carrión, R.; Villamil, L.V.; Corella, D.; Coltell, O. Association between MicrobiomeRelated Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population. Medicina 2022, 58, 1238. https://doi.org/ 10.3390/medicina58091238 | ca_CA |
dc.identifier.uri | http://hdl.handle.net/10234/202034 | |
dc.description.abstract | Background and Objectives: The gut microbiota has been increasingly recognized as a relevant factor associated with metabolic diseases. However, directly measuring the microbiota composition is a limiting factor for several studies. Therefore, using genetic variables as proxies for the microbiota composition is an important issue. Landmark microbiome–host genome-wide association studies (mbGWAS) have identified many SNPs associated with gut microbiota. Our aim was to analyze the association between relevant microbiome-related genetic variants (Mi-RSNPs) and fasting glucose and type 2 diabetes in a Mediterranean population, exploring the interaction with Mediterranean diet adherence. Materials and Methods: We performed a cross-sectional study in a high-cardiovascular-risk Mediterranean population (n = 1020), analyzing the association of Mi-RSNPs (from four published mbGWAS) with fasting glucose and type 2 diabetes. A single-variant approach was used for fitting fasting glucose and type 2 diabetes to a multivariable regression model. In addition, a Mendelian randomization analysis with multiple variants was performed as a sub-study. Results: We obtained several associations between Mi-RSNPs and fasting plasma glucose involving gut Gammaproteobacteria_HB, the order Rhizobiales, the genus Rumminococcus torques group, and the genus Tyzzerella as the top ranked. For type 2 diabetes, we also detected significant associations with Mi-RSNPs related to the order Rhizobiales, the family Desulfovibrionaceae, and the genus Romboutsia. In addition, some Mi-RSNPs and adherence to Mediterranean diet interactions were detected. Lastly, the formal Mendelian randomization analysis suggested combined effects. Conclusions: Although the use of Mi-RSNPs as proxies of the microbiome is still in its infancy, and although this is the first study analyzing such associations with fasting plasma glucose and type 2 diabetes in a Mediterranean population, some interesting associations, as well as modulations, with adherence to the Mediterranean diet were detected in these high-cardiovascular-risk subjects, eliciting new hypotheses. | ca_CA |
dc.format.extent | 21 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | MDPI | ca_CA |
dc.relation.isPartOf | Medicina, 2022, 58. | ca_CA |
dc.rights | © 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/). | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | glucose | ca_CA |
dc.subject | genetics | ca_CA |
dc.subject | microbiome | ca_CA |
dc.subject | Mendelian randomization | ca_CA |
dc.subject | diet | ca_CA |
dc.subject | Mediterranean | ca_CA |
dc.title | Association between Microbiome-Related Human Genetic Variants and Fasting Plasma Glucose in a High-Cardiovascular-Risk Mediterranean Population | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.3390/medicina58091238 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.mdpi.com/1648-9144/58/9/1238 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
project.funder.name | Instituto de Salud Carlos III | ca_CA |
project.funder.name | Ministerio de Economía y Competitividad | ca_CA |
project.funder.name | Fondo Europeo de Desarrollo Regional | ca_CA |
oaire.awardNumber | PROMETEO 17/2017 | ca_CA |
oaire.awardNumber | PROMETEO/2021/021 | ca_CA |
oaire.awardNumber | APOSTD/2019/136 | ca_CA |
oaire.awardNumber | APOSTD/2020/164 | ca_CA |
oaire.awardNumber | CIBER 06/03 | ca_CA |
oaire.awardNumber | SAF2016–80532-R | ca_CA |
oaire.awardNumber | PID2019-108858RB-I00 | ca_CA |
oaire.awardNumber | AEI 10.13039/501100011033 | ca_CA |
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