The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists
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Otros documentos de la autoría: Yohn, Samantha E.; Santerre, Jessica L.; Nunes, Eric J.; Kozak, Rouba; Podurgiel, Samantha J.; Correa, Merce; Salamone, John
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Título
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonistsAutoría
Fecha de publicación
2015Editor
ElsevierISSN
0091-3057; 1873-5177Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0091305715001446Palabras clave / Materias
Resumen
Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry
involved in behavioral activation and effort-related processes. Although much is known about the chara ... [+]
Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry
involved in behavioral activation and effort-related processes. Although much is known about the characteristics
of DA D2 receptor antagonism on effort-related choice behavior, less is known about the effects of D1 antagonism,
and agonist/antagonist interactions. The highly selective D1 antagonist ecopipam was studied for its effects on
effort-related choice behavior using the concurrent fixed ratio (FR) 5/chow feeding choice and T-maze barrier
choice procedures. In rats tested on the FR5/chow feeding choice task, ecopipam shifted choice behavior, decreasing
lever pressing for preferred high carbohydrate pellets but increasing consumption of lab chow. Also,
ecopipam decreased selection of the high effort option (i.e., climbing the barrier to obtain a larger reward) in
rats tested on the T-maze task, but did not disrupt arm preference or discrimination when no barrier was present.
The D1 agonists SKF38393, SKF81297 and A77636 were assessed for their ability to reverse the effects of
ecopipam, and in each case the D1 agonist significantly attenuated the effects of ecopipam, typically with an
inverted-u shaped dose/response curve. SKF81297 also was able to reverse the effects of the catecholamine depleting
agent tetrabenazine on T-maze performance. In summary, the present results implicate DA D1 receptors
in the regulation of behavioral activation and effort-related functions, and demonstrate the utility of using tests of
effort-related choice behavior for assessing the effects of D1 agonists. [-]
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Pharmacology, Biochemistry and Behavior 135 (2015) 217–226Derechos de acceso
0091-3057/© 2015 Published by Elsevier Inc.
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