2024-03-29T14:32:39Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1600872024-01-25T11:42:19Zcom_10234_8033com_10234_9col_10234_8636
00925njm 22002777a 4500
dc
Yohn, Samantha E.
author
Santerre, Jessica L.
author
Nunes, Eric J.
author
Kozak, Rouba
author
Podurgiel, Samantha J.
author
Correa, Merce
author
Salamone, John
author
2015
Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry
involved in behavioral activation and effort-related processes. Although much is known about the characteristics
of DA D2 receptor antagonism on effort-related choice behavior, less is known about the effects of D1 antagonism,
and agonist/antagonist interactions. The highly selective D1 antagonist ecopipam was studied for its effects on
effort-related choice behavior using the concurrent fixed ratio (FR) 5/chow feeding choice and T-maze barrier
choice procedures. In rats tested on the FR5/chow feeding choice task, ecopipam shifted choice behavior, decreasing
lever pressing for preferred high carbohydrate pellets but increasing consumption of lab chow. Also,
ecopipam decreased selection of the high effort option (i.e., climbing the barrier to obtain a larger reward) in
rats tested on the T-maze task, but did not disrupt arm preference or discrimination when no barrier was present.
The D1 agonists SKF38393, SKF81297 and A77636 were assessed for their ability to reverse the effects of
ecopipam, and in each case the D1 agonist significantly attenuated the effects of ecopipam, typically with an
inverted-u shaped dose/response curve. SKF81297 also was able to reverse the effects of the catecholamine depleting
agent tetrabenazine on T-maze performance. In summary, the present results implicate DA D1 receptors
in the regulation of behavioral activation and effort-related functions, and demonstrate the utility of using tests of
effort-related choice behavior for assessing the effects of D1 agonists.
0091-3057
1873-5177
http://hdl.handle.net/10234/160087
http://dx.doi.org/10.1016/j.pbb.2015.05.003
Dopamine
D1 receptor
Nucleus accumbens
Behavioral activation
Motivation
Depression
Fatigue
Anergia
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists