Listar por autoría "7c964589-f009-45a1-b4ae-a0d448d8cf26"
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Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology
Salamone, John; Yohn, Samantha E.; López Cruz, Laura; San Miguel Segura, Noemí; Correa, Merce Oxford University Press (2016-04-26)Motivation has been defined as the process that allows organisms to regulate their internal and external environment, and control the probability, proximity and availability of stimuli. As such, motivation is a complex ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Yohn, Samantha E.; Alberati, Daniela; Correa, Merce; Salamone, John Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Assessment of a glycine uptake inhibitor in animal models of effort-related choice behavior: implications for motivational dysfunctions
Yohn, Samantha E.; Alberati, Daniela; Correa, Merce; Salamone, John Springer Verlag (2017)Rationale Motivated behavior can be characterized by a substantial exertion of effort, and organisms often make effortrelated decisions based upon analyses of work-related response costs and reinforcement preference. ... -
Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
Yohn, Samantha E.; Errante, Emily E.; Rosenbloom Snow, Aaron; Somerville, Matthew; Rowland, Margaret; Tokarski, Kristin; Zafar, Nadia; Correa, Merce; Salamone, John Elsevier (2016)Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ... -
Effects of lisdexamfetamine and s-citalopram, alone and in combination, on effort-related choice behavior in the rat
Yohn, Samantha E.; López Cruz, Laura; Hutson, Peter H.; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Effort-related motivational symptoms, such as anergia, psychomotor retardation, and fatigue, are an important aspect of depression and other disorders. Motivational symptoms are resistant to some treatments, ... -
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
Yohn, Samantha E.; Arif, Yumna; Haley, Allison; Tripodi, Guiseppe; Baqi, Younis; Müller, Christa E.; San Miguel Segura, Noemí; Correa, Merce; Salamone, John Springer Verlag (2016)Rationale Motivational dysfunctions such as anergia, fatigue, and reduced effort expenditure are common in patients with depression and other disorders. Pro-inflammatory cytokines are implicated in depression, and ... -
Evaluation of the effort-related motivational effects of the novel dopamine uptake inhibitor PRX-14040
Yohn, Samantha E.; Gogoj, Augustyna; Haque, Aileen; López Cruz, Laura; Haley, Allison; Huxley, Philip; Baskin, Patricia; Correa, Merce; Salamone, John Elsevier (2016)Psychiatric disorders are often marked by effort-related motivational symptoms such as anergia, fatigue, psychomotor retardation, and alterations in effort-based decision making. Animal studies of effort-related choice ... -
Oral Ingestion and Intraventricular Injection of Curcumin Attenuates the Effort-Related Effects of the VMAT-2 Inhibitor Tetrabenazine: Implications for Motivational Symptoms of Depression
Yohn, Samantha E.; Gorka, Dea; Mistry, Anisha; Collins, Samantha; Qian, Emily; Correa, Merce; Manchanda, Arushi; Bogner, Robin; Salamone, John American Chemical Society (2017-09)Effort-related choice tasks are used for studying depressive motivational symptoms such as anergia/fatigue. These studies investigated the ability of the dietary supplement curcumin to reverse the low-effort bias induced ... -
Partial reversal of the effort-related motivational effects of tetrabenazinewith the MAO-B inhibitor deprenyl (selegiline): Implications for treatingmotivational dysfunctions
Contreras Mora, Héctor; Rowland, Margaret; Yohn, Samantha E.; Correa, Merce; Salamone, John Elsevier (2018)People with depression and Parkinsonism frequently show effort-related motivational symptoms, such as an-ergia, psychomotor retardation, and fatigue. Tasks that assess effort-related choice are being used as animalmodels of ... -
The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine
Podurgiel, Samantha J.; Yohn, Samantha E.; Dortche, Kristina; Correa, Merce; Salamone, John Elsevier (2016)Tetrabenazine (TBZ) is prescribed for the treatment of chorea associated with Huntington’s disease. Via inhibition of the vesicular monoamine transporter (VMAT-2), TBZ blocks dopamine (DA) storage and depletes striatal DA; ... -
The monoamine-oxidase B inhibitor deprenyl increases selection of high-effort activity in rats tested on a progressive ratio/chow feeding choice procedure: Implications for treating motivational dysfunctions
Yohn, Samantha E.; Reynolds, Shanika; Tripodi, Guiseppe; Correa, Merce; Salamone, John Elsevier (2018-04)Motivated behaviors often are characterized by a high degree of behavioral activation and work output, and organisms frequently make effort-related decisions based upon cost/benefit analyses. Moreover, people with depression ... -
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
Salamone, John; Correa, Merce; Yohn, Samantha E.; López Cruz, Laura; San Miguel Segura, Noemí; Alatorre, Luisa Elsevier (2016)This review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts ... -
The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists
Yohn, Samantha E.; Santerre, Jessica L.; Nunes, Eric J.; Kozak, Rouba; Podurgiel, Samantha J.; Correa, Merce; Salamone, John Elsevier (2015)Mesolimbic dopamine (DA), particularly in the nucleus accumbens, is a critical component of the brain circuitry involved in behavioral activation and effort-related processes. Although much is known about the characteristics of ... -
The vesicular monoamine transporter (VMAT-2) inhibitor tetrabenazine induces tremulous jaw movements in rodents: Implications for pharmacological models of parkinsonian tremor
López Cruz, Laura; Podurgiel, Samantha J.; Nunes, Eric J.; Yohn, Samantha E.; Barber, J.; Thompson, A.; Milligan, M.; Lee, Christie A.; Pardo Andrés, Marta; Valverde, Olga; LEDENT, Catherine; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Elsevier (2013)Tetrabenazine (TBZ) is a reversible inhibitor of vesicular monoamine storage that is used to treat Huntington’s disease. TBZ preferentially depletes striatal dopamine (DA), and patients being treated with TBZ often experience ... -
The VMAT-2 Inhibitor Tetrabenazine Affects EffortRelated Decision Making in a Progressive Ratio/Chow Feeding Choice Task: Reversal with Antidepressant Drugs
Randall, Patrick A.; Lee, Christie A.; Nunes, Eric J.; Yohn, Samantha E.; Nowak, Victoria; Khan, Bilal; Shah, Priya; Pandit, Saagar; Vemuri, Venkata Kiran; Makriyannis, Alexandros; Baqi, Younis; Müller, Christa E.; Correa, Merce; Salamone, John Public Library of Science (2014)Behavioral activation is a fundamental feature of motivation, and organisms frequently make effort-related decisions based upon evaluations of reinforcement value and response costs. Furthermore, people with major depression ... -
The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A2A antagonist MSX-3 and the catecholamine uptake blocker bupropion
Yohn, Samantha E.; Thompson, Christian; Randall, Patrick A.; Lee, Christie A.; Müller, Christa E.; Baqi, Younis; Correa, Merce; Salamone, John Springer Verlag (2015)Rationale Depressed people show effort-related motivational symptoms, such as anergia, retardation, lassitude, and fatigue. Animal tests can model these motivational symptoms, and the present studies characterized the ...