Buscar
Partial reversal of the effort-related motivational effects of tetrabenazinewith the MAO-B inhibitor deprenyl (selegiline): Implications for treatingmotivational dysfunctions
(Elsevier, 2018)
People with depression and Parkinsonism frequently show effort-related motivational symptoms, such as an-ergia, psychomotor retardation, and fatigue. Tasks that assess effort-related choice are being used as animalmodels of ...
Preference for Exercise vs. More Sedentary Reinforcers: Validation of an Animal Model of Tetrabenazine-Induced Anergia
(Frontiers Media, 2020-01-30)
Physical activities can have intrinsic motivational or reinforcing properties. The choice
to engage in voluntary physical activity is undertaken in relation to the selection of
other alternatives, such as sedentary ...
Dopamine, Effort-Based Choice, and Behavioral Economics: Basic and Translational Research
(Frontiers Media, 2018-03)
Operant behavior is not only regulated by factors related to the quality or quantity of
reinforcement, but also by the work requirements inherent in performing instrumental
actions. Moreover, organisms often make ...
Effort-related decision making in humanized COMT mice: Effects ofVal158Met polymorphisms and possible implications for negative symptomsin humans
(Elsevier, 2020)
Catechol-o-methyltransferase (COMT) is an enzyme that metabolizes catecholamines, and is crucial for clearanceof dopamine (DA) in prefrontal cortex. Val158Met polymorphism, which causes a valine (Val) to methionine(Met) ...
The Novel Atypical Dopamine Uptake Inhibitor (S)-CE-123 Partially Reverses the Effort-Related Effects of the Dopamine Depleting Agent Tetrabenazine and Increases Progressive Ratio Responding
(Frontiers Media, 2019-06-28)
Animal studies of effort-based choice behavior are being used to model effort-related
motivational dysfunctions in humans. With these procedures, animals are offered a choice
between high-effort instrumental actions ...
The non-selective adenosine antagonist theophylline reverses the effects of dopamine antagonism on tremor, motor activity and effort-based decision-making
(Elsevier, 2020)
Considerable evidence indicates that adenosine and dopamine systems interact in the regulation of basal ganglia function. Nonselective adenosine antagonists such as the methylxanthine caffeine as well as selective adenosine ...
Blockade of uptake for dopamine, but not norepinephrine or 5-HT, increases selection of high effort instrumental activity: Implications for treatment of effort-related motivational symptoms in psychopathology
(Elsevier, 2016)
Deficits in behavioral activation, exertion of effort, and other psychomotor/motivational symptoms are frequently seen in people with depression and other disorders. Depressed people show a decision bias towards selection ...
Behavioral and dopamine transporter binding properties of the modafinil analog (S, S)-CE-158: reversal of the motivational effects of tetrabenazine and enhancement of progressive ratio responding
(Springer, 2020)
Rationale Atypical dopamine (DA) transport blockers such as modafinil and its analogs may be useful for treating motivational
symptoms of depression and other disorders. Previous research has shown that the DA depleting ...
Effort-related motivational effects of the pro-inflammatory cytokine interleukin-6: pharmacological and neurochemical characterization
(Springer Verlag, 2016)
Rationale
Motivational dysfunctions such as anergia, fatigue,
and reduced effort expenditure are common in patients with
depression and other disorders. Pro-inflammatory cytokines
are implicated in depression, and ...
The pharmacology of effort-related choice behavior: Dopamine, depression, and individual differences
(Elsevier, 2016)
This review paper is focused upon the involvement of mesolimbic dopamine (DA) and related brain systems in effort-based processes. Interference with DA transmission affects instrumental behavior in a manner that interacts ...