CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivo
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Otros documentos de la autoría: Carrillo-de Sauvage, María Ángeles; Gómez, Aurora; Ros Gómez, Carmen María; Ros Bernal, Francisco; Martín, Eduardo D.; Pérez Vallés, Ana; Gallego Sánchez, José María; Fernández Villalba, Emiliano; Barcia Sr., Carlos; Barcia, Carlos; Herrero Ezquerro, María Trinidad
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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Título
CCL2-Expressing astrocytes mediate the extravasation of T lymphocytes in the brain. Evidence from patients with glioma and experimental models in vivoAutoría
Fecha de publicación
2012Editor
Public Library of ScienceISSN
1932-6203; 1932-6203Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.plosone.org/article/fetchObject.action?uri=info%3Adoi%2F10.1371%2Fjou ...Versión
info:eu-repo/semantics/publishedVersionResumen
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in
the parenchyma is unclear. Imaging of the cell type responsible for this task and details on ... [+]
CCL2 is a chemokine involved in brain inflammation, but the way in which it contributes to the entrance of lymphocytes in
the parenchyma is unclear. Imaging of the cell type responsible for this task and details on how the process takes place in
vivo remain elusive. Herein, we analyze the cell type that overexpresses CCL2 in multiple scenarios of T-cell infiltration in the
brain and in three different species. We observe that CCL2+ astrocytes play a part in the infiltration of T-cells in the brain and
our analysis shows that the contact of T-cells with perivascular astrocytes occurs, suggesting that may be an important
event for lymphocyte extravasation [-]
Publicado en
PLoS ONE, February, Volume 7 Issue 2 e30762Derechos de acceso
info:eu-repo/semantics/openAccess
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Excepto si se señala otra cosa, la licencia del ítem se describe como: 2012 Carrillo-de Sauvage et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which
permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited