Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
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http://dx.doi.org/10.1016/j.ejmech.2011.02.011 |
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Título
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubulesAutor (es)
Fecha de publicación
2011-05Editor
ElsevierResumen
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active ... [+]
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities [-]
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info:eu-repo/semantics/articleDerechos de acceso
info:eu-repo/semantics/restrictedAccess
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