Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules

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comunitat-uji-handle:10234/9

comunitat-uji-handle2:10234/7053

comunitat-uji-handle3:10234/8639

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http://dx.doi.org/10.1016/j.ejmech.2011.02.011

Metadata

Title
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
Author (s)
Marco, J. Alberto;
García Pla, Jorge;
Carda, MiguelOrcidResearcherID;
Murga, JuanOrcidResearcherID;
Falomir, Eva;
Trigili, Chiara;
Notararigo, Sara;
Díaz, J. Fernando;
Barasoain, Isabel
Date
2011-05
URI
http://hdl.handle.net/10234/50159
DOI
http://dx.doi.org/10.1016/j.ejmech.2011.02.011
Publisher
Elsevier
Abstract
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active ... [+]
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities [-]
Subject
Type
info:eu-repo/semantics/article
Rights
info:eu-repo/semantics/restrictedAccess
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