Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubules
Impacto
Scholar |
Otros documentos de la autoría: Marco, J. Alberto; García Pla, Jorge; Carda, Miguel; Murga, Juan; Falomir, Eva; Trigili, Chiara; Notararigo, Sara; Díaz, J. Fernando; Barasoain, Isabel
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http://dx.doi.org/10.1016/j.ejmech.2011.02.011 |
Metadatos
Título
Design and synthesis of pironetin analogues with simplified structure and study of their interactions with microtubulesAutoría
Fecha de publicación
2011-05Editor
ElsevierTipo de documento
info:eu-repo/semantics/articlePalabras clave / Materias
Resumen
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active ... [+]
The preparation of a series of pironetin analogues with simplified structure is described. Their cytotoxic activity and their interactions with tubulin have been investigated. It has been found that, while less active than the parent molecule, the pironetin analogues still share the mechanism of action of the latter and compete for the same binding site to α-tubulin. Variations in the configurations of their stereocenters do not translate into relevant differences between biological activities [-]
Publicado en
European Journal of Medicinal ChemistryDerechos de acceso
http://rightsstatements.org/vocab/CNE/1.0/
info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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