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Ag Nanoparticles/α-Ag2WO4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
dc.contributor.author | Assis, Marcelo de | |
dc.contributor.author | Robeldo, Thaiane | |
dc.contributor.author | Foggi, Camila Cristina | |
dc.contributor.author | Kubo, A.M. | |
dc.contributor.author | Mínguez-Vega, Gladys | |
dc.contributor.author | Cordoncillo, Eloisa | |
dc.contributor.author | Beltrán Mir, Héctor | |
dc.contributor.author | Torres-Mendieta, Rafael | |
dc.contributor.author | Andres, Juan | |
dc.contributor.author | Oliva, Mónica | |
dc.contributor.author | Vergani, Carlos | |
dc.contributor.author | Barbugli, P.A. | |
dc.contributor.author | Camargo, E.R. | |
dc.contributor.author | Borra, Ricardo Carneiro | |
dc.contributor.author | Longo, Elson | |
dc.date.accessioned | 2019-09-24T18:27:09Z | |
dc.date.available | 2019-09-24T18:27:09Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | ASSIS, M., et al. Ag Nanoparticles/α-Ag 2 WO 4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents. Scientific reports, 2019, vol. 9, núm. 1, p. 9927 | ca_CA |
dc.identifier.issn | 2045-2322 | |
dc.identifier.uri | http://hdl.handle.net/10234/183922 | |
dc.description.abstract | The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected. | ca_CA |
dc.format.extent | 15 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Nature Research | ca_CA |
dc.publisher | Nature Research (part of Springer Nature) | ca_CA |
dc.relation.isPartOf | Scientific reports, 2019, vol. 9, núm. 1, p. 9927 | ca_CA |
dc.rights | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. © The Author(s) 2019 | ca_CA |
dc.rights | Atribución 4.0 Internacional | * |
dc.rights.uri | http://creativecommons.org/licenses/by-sa/4.0/ | * |
dc.subject | biomaterials | ca_CA |
dc.subject | cancer | ca_CA |
dc.title | Ag Nanoparticles/α-Ag2WO4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1038/s41598-019-46159-y | |
dc.relation.projectID | All authors acknowledge to the Servei Central d’Instrumentació Científica for the use of the femtosecond laser facility; CAPES, FAPESP (2013/07296-2; 2013/26671-9; 2017/12594-3), CNPq (166281/2017-4) and Enio Longo for the support given in the realization and creation of the images. H.B-M and E.C. thank the Universidad Jaume I (Project UJI-B2016-38) and Ministerio de Economia, Industria y Competitividad (Project MAT2016-80410-P) for financial support. G.M.V thank Generalitat Valenciana for Prometeo/2016/079 and Ministerio de Economía y Competitividad project FIS2016-75618-R. R. T-.M. acknowledge the Ministry of Education, Youth and Sports of the Czech Republic and the European Union for the funds Hybrid Materials for Hierarchical Structures (HyHi, Reg. No. CZ.02.1.01/0.0/0.0/16_019/0000843) and the “National Programme for Sustainability I” LO 1201. | ca_CA |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.nature.com/articles/s41598-019-46159-y | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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Excepto si se señala otra cosa, la licencia del ítem se describe como: Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Cre-ative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not per-mitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
© The Author(s) 2019