comunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
comunitat-uji-handle4:
INVESTIGACION
Metadades
Títol
Ag Nanoparticles/α-Ag2WO4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents
Data de publicació
2019
Editor
Nature Research; Nature Research (part of Springer Nature)
ISSN
2045-2322
Cita bibliogràfica
ASSIS, M., et al. Ag Nanoparticles/α-Ag 2 WO 4 Composite Formed by Electron Beam and Femtosecond Irradiation as Potent Antifungal and Antitumor Agents. Scientific reports, 2019, vol. 9, núm. 1, p. 9927
Tipus de document
info:eu-repo/semantics/article
Versió
info:eu-repo/semantics/publishedVersion
Resum
The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and ... [+]
The ability to manipulate the structure and function of promising systems via external stimuli is emerging with the development of reconfigurable and programmable multifunctional materials. Increasing antifungal and antitumor activity requires novel, effective treatments to be diligently sought. In this work, the synthesis, characterization, and in vitro biological screening of pure α-Ag2WO4, irradiated with electrons and with non-focused and focused femtosecond laser beams are reported. We demonstrate, for the first time, that Ag nanoparticles/α-Ag2WO4 composite displays potent antifungal and antitumor activity. This composite had an extreme low inhibition concentration against Candida albicans, cause the modulation of α-Ag2WO4 perform the fungicidal activity more efficient. For tumor activity, it was found that the composite showed a high selectivity against the cancer cells (MB49), thus depleting the populations of cancer cells by necrosis and apoptosis, without the healthy cells (BALB/3T3) being affected. [-]
Publicat a
Scientific reports, 2019, vol. 9, núm. 1, p. 9927
Proyecto de investigación
All authors acknowledge to the Servei Central d’Instrumentació Científica for the use of the femtosecond laser facility; CAPES, FAPESP (2013/07296-2; 2013/26671-9; 2017/12594-3), CNPq (166281/2017-4) and Enio Longo for the support given in the realization and creation of the images. H.B-M and E.C. thank the Universidad Jaume I (Project UJI-B2016-38) and Ministerio de Economia, Industria y Competitividad (Project MAT2016-80410-P) for financial support. G.M.V thank Generalitat Valenciana for Prometeo/2016/079 and Ministerio de Economía y Competitividad project FIS2016-75618-R. R. T-.M. acknowledge the Ministry of Education, Youth and Sports of the Czech Republic and the European Union for the funds Hybrid Materials for Hierarchical Structures (HyHi, Reg. No. CZ.02.1.01/0.0/0.0/16_019/0000843) and the “National Programme for Sustainability I” LO 1201.
Drets d'accés
info:eu-repo/semantics/openAccess
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