Obesity impairs leukocyte‐endothelium cell interactions and oxidative stress in humans
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Otros documentos de la autoría: López Doménech, Sandra; Bañuls, Celia; Díaz Morales, Noelia; Escribano López, Irene; Morillas, Carlos; Veses, Silvia; Orden, Samuel; Álvarez, Ángeles; Víctor, Víctor M.; Hernández Mijares, Antonio; Rocha, Milagros
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https://doi.org/10.1111/eci.12985 |
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Título
Obesity impairs leukocyte‐endothelium cell interactions and oxidative stress in humansAutoría
Fecha de publicación
2018-08Editor
WileyCita bibliográfica
LÓPEZ DOMÉNECH, Sandra; BAÑULS, Celia; DÍAZ MORALES, Noelia; ESCRIBANO LÓPEZ, Irene; MORILLAS, Carlos; VESES, Silvia; ORDEN, Samuel; ÁLVAREZ, Ángeles; VÍCTOR, Víctor M.; HERNÁNDEZ MIJARES, Antonio; ROCHA, Milagros (2018). Obesity impairs leukocyte‐endothelium cell interactions and oxidative stress in humans. European Journal of Clinical Investigation (2018), v. 48, issue 8, p.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
European Journal of Clinical Investigation (2018), v. 48, issue 8Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Background:To evaluate the relationship between leukocyte‐endothelial cellinteractions and oxidative stress parameters in non‐diabetic patients with differentgrades of obesity.Material and methods:For this cross‐sec ... [+]
Background:To evaluate the relationship between leukocyte‐endothelial cellinteractions and oxidative stress parameters in non‐diabetic patients with differentgrades of obesity.Material and methods:For this cross‐sectional study, 225 subjects wererecruited from January 1, 2014 to December 31, 2016 and divided into groupsaccording to BMI (<30 kg/m2,30‐40 kg/m2and >40 kg/m²). We determined clin-ical parameters, systemic inflammatory markers, soluble cellular adhesion mole-cules, leukocyte‐endothelium cell interactions—rolling flux, velocity and adhesion—, oxidative stress parameters—total ROS, total superoxide, glutathione—andmitochondrial membrane potential in leukocytes.Results:We verified that HOMA‐IR and hsCRP increased progressively as obe-sity developed, whereas A1c, IL6 and TNFαwere augmented in the BMI > 40kg/m² group. The cellular adhesion molecule sP‐selectin was increased in patientswith obesity, while sICAM, total ROS, total superoxide and mitochondrial mem-brane potential were selectively higher in the BMI > 40 kg/m² group. Obesityinduced a progressive decrease in rolling velocity and an enhancement of rollingflux and leukocyte adhesion.Conclusion:Our findings reveal that endothelial dysfunction markers are alteredin human obesity and are associated with proinflammatory cytokines andincreased oxidative stress parameters. [-]
Proyecto de investigación
1) Grants PI16/00301, PI16/01083 and PI15/01424 andCIBERehd CB06/04/0071 from Carlos IIIHealth Institute ; 2) SAF2015-67678-Rfrom Ministry of Economy andCompetitiveness; 3) European Regional Development Fund(ERDF“A way to build Europe”),PROMETEOII 2014/035; 4) GV/2016/169from the Regional Ministry Education ofValencian Community; 5) UGP-15-193 and UGP-15-220 from FISABIO; 6) Ministry of Health of the Valencian Regional Government and Carlos III Health Institute (CES10/030 and CP16/00037); 7) predoctoral fellowship fromCarlos III Health Institute (FI14/00350 andFI14/00125); 8) FISABIO (UGP-15-144); 9) Postdoctoral contract from Carlos III Health Institute (CD14/00043)Derechos de acceso
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info:eu-repo/semantics/restrictedAccess
info:eu-repo/semantics/restrictedAccess
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