Listar por autoría "ff216e07-5a4b-4e8c-8143-d3a8bf5b9780"
Mostrando ítems 1-4 de 4
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Abacavir induces platelet-endothelium interactions by interfering with purinergic signalling: A step from inflammation to thrombosis
Álvarez, Ángeles; Rios-Navarro, Cesar; Blanch-Ruiz, Maria Amparo; Collado-Diaz, Victor; Andújar, Isabel; Martinez-Cuesta, Maria Angeles; Orden, Samuel; Esplugues Mota, Juan V. Elsevier (2017-05)The controversy connecting Abacavir (ABC) with cardiovascular disease has been fuelled by the lack of a credible mechanism of action. ABC shares structural similarities with endogenous purines, signalling molecules capable ... -
Efavirenz and the CNS: what we already know and questions that need to be answered
Apostolova, Nadezda; Funes, Haryes A.; Blas García, Ana; Galindo, Maria J.; Álvarez, Ángeles; Esplugues, Juan V. Oxford University Press (2015-07)The NNRTI efavirenz has long been one of the most frequently employed antiretroviral drugs in the multidrug regimens used to treat HIV infection, in accordance with its well-demonstrated antiretroviral efficacy and ... -
Neuronal Bioenergetics and Acute Mitochondrial Dysfunction: A Clue to Understanding the Central Nervous System Side Effects of Efavirenz
Funes, Haryes A.; Apostolova, Nadezda; Alegre, Fernando; Blas García, Ana; Álvarez, Ángeles; Martí Cabrera, Miguel; Esplugues Mota, Juan V. Oxford University Press (2014-05)Background. Neurological pathogenesis is associated with mitochondrial dysfunction and differences in neuronal/glial handling of oxygen and glucose. The main side effects attributed to efavirenz involve the CNS, but the ... -
Obesity impairs leukocyte‐endothelium cell interactions and oxidative stress in humans
López Doménech, Sandra; Bañuls, Celia; Díaz Morales, Noelia; Escribano López, Irene; Morillas, Carlos; Veses, Silvia; Orden, Samuel; Álvarez, Ángeles; Víctor, Víctor M.; Hernández Mijares, Antonio; Rocha, Milagros Wiley (2018-08)Background:To evaluate the relationship between leukocyte‐endothelial cellinteractions and oxidative stress parameters in non‐diabetic patients with differentgrades of obesity.Material and methods:For this cross‐sectional ...