On the different sources of cooperativity in pH titrating sites of a membrane protein channel
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http://dx.doi.org/10.1140/epje/i2016-16029-2 |
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Title
On the different sources of cooperativity in pH titrating sites of a membrane protein channelDate
2016Publisher
EDP Sciences; Società Italiana di Fisica; Springer-VerlagISSN
1292-8941; 1292-895XBibliographic citation
ALCARAZ, Antonio; QUERALT-MARTÍN, María. On the different sources of cooperativity in pH titrating sites of a membrane protein channel. The European Physical Journal E, 2016, vol. 39, no 3, p. 1-6.Type
info:eu-repo/semantics/articlePublisher version
http://link.springer.com/article/10.1140%2Fepje%2Fi2016-16029-2Version
info:eu-repo/semantics/publishedVersionSubject
Abstract
Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of ... [+]
Cooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of different experiments, even involving site-directed mutagenesis, to identify the different sources of cooperativity and to discriminate between genuine and apparent cooperativity. We discuss the implications for the channel function in the bacterial porins PorA (N. meningitidis) and OmpF (E. coli) and the viroporin SARS-CoV E. [-]
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The European Physical Journal E, 2016, vol. 39, no 3Rights
© EDP Sciences / Società Italiana di Fisica / Springer-Verlag
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