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dc.contributor.authorAlcaraz González, Antonio
dc.contributor.authorQueralt Martín, María
dc.date.accessioned2016-05-31T11:21:01Z
dc.date.available2016-05-31T11:21:01Z
dc.date.issued2016
dc.identifier.citationALCARAZ, Antonio; QUERALT-MARTÍN, María. On the different sources of cooperativity in pH titrating sites of a membrane protein channel. The European Physical Journal E, 2016, vol. 39, no 3, p. 1-6.ca_CA
dc.identifier.issn1292-8941
dc.identifier.issn1292-895X
dc.identifier.urihttp://hdl.handle.net/10234/160135
dc.description.abstractCooperative interactions play a central role in the regulation of protein functions. Here we show that in multi-site systems like ion channels the application of the Hill formalism could require a combination of different experiments, even involving site-directed mutagenesis, to identify the different sources of cooperativity and to discriminate between genuine and apparent cooperativity. We discuss the implications for the channel function in the bacterial porins PorA (N. meningitidis) and OmpF (E. coli) and the viroporin SARS-CoV E.ca_CA
dc.description.sponsorShipWe wish to acknowledge the support from the Spanish Ministry of Economy and Competitiveness (MINECO Project FIS2013- 40473-P) and the Fundació Caixa Castelló-Bancaixa (Project no. P1-1B2015-28).ca_CA
dc.format.extent6 p.ca_CA
dc.format.mimetypeapplication/pdfca_CA
dc.language.isoengca_CA
dc.publisherEDP Sciencesca_CA
dc.publisherSocietà Italiana di Fisicaca_CA
dc.publisherSpringer-Verlagca_CA
dc.relation.isPartOfThe European Physical Journal E, 2016, vol. 39, no 3ca_CA
dc.rights© EDP Sciences / Società Italiana di Fisica / Springer-Verlagca_CA
dc.subjectliving systems: structure and functionca_CA
dc.subjectprotein functionsca_CA
dc.subjectmeningitidisca_CA
dc.subjectmembrane proteinsca_CA
dc.titleOn the different sources of cooperativity in pH titrating sites of a membrane protein channelca_CA
dc.typeinfo:eu-repo/semantics/articleca_CA
dc.identifier.doihttp://dx.doi.org/10.1140/epje/i2016-16029-2
dc.rights.accessRightsinfo:eu-repo/semantics/restrictedAccessca_CA
dc.relation.publisherVersionhttp://link.springer.com/article/10.1140%2Fepje%2Fi2016-16029-2ca_CA


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