Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances
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Otros documentos de la autoría: Ibáñez, Maria; Sancho, Juan V; Bijlsma, Lubertus; van Nuijs, Alexander; Covaci, Adrian; Hernandez, Felix
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http://dx.doi.org/10.1016/j.trac.2014.02.009 |
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Título
Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substancesAutoría
Fecha de publicación
2014-05Editor
ElsevierCita bibliográfica
IBÁÑEZ, María, et al. Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances. TrAC Trends in Analytical Chemistry, 2014, 57: 107-117.Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
http://www.sciencedirect.com/science/article/pii/S0165993614000417Palabras clave / Materias
Resumen
In the past decade, an increasing number of new psychoactive substances (NPSs) were introduced on the drug markets through various modes of distribution, including the and smart shops. Recent reports on their adverse ... [+]
In the past decade, an increasing number of new psychoactive substances (NPSs) were introduced on the drug markets through various modes of distribution, including the and smart shops. Recent reports on their adverse effects produced alarming social concern. Detection of such NPSs is a challenge due to their quick introduction, creating a constantly moving analytical target. Modern analytical chemistry can give a rapid, efficient answer by detecting and identifying the compounds responsible for harmful effects. High-resolution mass spectrometry (HRMS) is a valuable analytical tool, as it provides sensitive, full-spectrum MS data with high mass resolution and mass accuracy. We evaluate different analytical strategies based on time-of-flight MS for screening and identifying NPSs. These strategies include unbiased non-target screening, target screening, and biased non-target screening. We explain and demonstrate these approaches with examples of NPSs investigated in herbal blends, pills, powders, drinkable solutions and truffles. [-]
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TrAC Trends in Analytical Chemistry Volume 57, May 2014Derechos de acceso
Copyright © 2014 Elsevier Ltd. All rights reserved.
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