2024-03-29T14:50:59Zhttps://repositori.uji.es/oai/requestoai:repositori.uji.es:10234/1255042024-03-27T13:50:22Zcom_10234_33596com_10234_9col_10234_33597
00925njm 22002777a 4500
dc
Ibáñez, Maria
author
Sancho, Juan V
author
Bijlsma, Lubertus
author
van Nuijs, Alexander
author
Covaci, Adrian
author
Hernandez, Felix
author
2014-05
In the past decade, an increasing number of new psychoactive substances (NPSs) were introduced on the drug markets through various modes of distribution, including the and smart shops. Recent reports on their adverse effects produced alarming social concern. Detection of such NPSs is a challenge due to their quick introduction, creating a constantly moving analytical target. Modern analytical chemistry can give a rapid, efficient answer by detecting and identifying the compounds responsible for harmful effects. High-resolution mass spectrometry (HRMS) is a valuable analytical tool, as it provides sensitive, full-spectrum MS data with high mass resolution and mass accuracy. We evaluate different analytical strategies based on time-of-flight MS for screening and identifying NPSs. These strategies include unbiased non-target screening, target screening, and biased non-target screening. We explain and demonstrate these approaches with examples of NPSs investigated in herbal blends, pills, powders, drinkable solutions and truffles.
IBÁÑEZ, María, et al. Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances. TrAC Trends in Analytical Chemistry, 2014, 57: 107-117.
http://hdl.handle.net/10234/125504
http://dx.doi.org/10.1016/j.trac.2014.02.009
biased non-target screening
high-resolution mass spectrometry
legal high
new psychoactive substance
psychoactive substance
quadrupole time-of-flight mass spectrometry
screening
target screening
time-of-flight mass spectrometry
unbiased non-target screening
Comprehensive analytical strategies based on high-resolution time-of-flight mass spectrometry to identify new psychoactive substances