Dopamine modulation affects the performance of parkinsonian patients in a precision motor task measured by an antropomorphic device
Scholar | Other documents of the author: Nombela, Cristina; Pedreño Molina, Juan Luis; Ros Bernal, Francisco; Molina Vilaplana, Javier; Fernández Villalba, Emiliano; López Coronado, Juan; Herrero Ezquerro, María Trinidad
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TitleDopamine modulation affects the performance of parkinsonian patients in a precision motor task measured by an antropomorphic device
Publisher versionhttp://ac.els-cdn.com/S0167945711001187/1-s2.0-S0167945711001187-main.pdf?_tid=1 ...
Several parameters related to the timing, grip force and load force involved in a precision grasping task were studied in patients with Parkinson’s disease (PD) at different moments of medication and healthy controls, ... [+]
Several parameters related to the timing, grip force and load force involved in a precision grasping task were studied in patients with Parkinson’s disease (PD) at different moments of medication and healthy controls, using a sensorized anthropomorphic device which was totally adapted to the human hand. The aim of this work was to carry out an accurate study of the reach-load-grip-hold-place-release subtasks to identify any physical motor impairment, its relation to medication and Parkinsonian strategies. Twenty seven patients in ON and OFF-like medication moments, and twenty seven age-matched controls took part in the experiment, which consisted of using the index finger and the thumb to perform a precision motor task involving different experimental objects. Visual cues were used as distracting elements. Results showed several motor parameters impaired in OFF-like medication moment but attenuated in ON state, suggesting a medication effect on the performance of the task. [-]
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