Listar por autoría "eb92322a-c1d6-446c-8eff-e8887791a833"
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Abscisic Acid Supplementation Rescues High Fat Diet-Induced Alterations in Hippocampal Inflammation and IRSs Expression
Ribes-Navarro, Alberto; Atef, Mariam; Sánchez-Sarasúa, Sandra; Beltrán Bretones, María Teresa; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2018)Accumulated evidence indicates that neuroinflammation induces insulin resistance in the brain. Moreover, both processes are intimately linked to neurodegenerative disorders, including Alzheimer’s disease. Potential mechanisms ... -
Acute oral administration of low doses of methylphenidate targets calretinin neurons in the rat septal area
García Avilés, Álvaro; Albert Gasco, Hector; Arnal Vicente, Isabel; Elhajj, Ebtisam; Sanjuán, Julio; Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E Frontiers Media (2015)Methylphenidate (MPD) is a commonly administered drug to treat children suffering from attention deficit hyperactivity disorder (ADHD). Alterations in septal driven hippocampal theta rhythm may underlie attention deficits ... -
Becoming stressed: Does the age matter? Reviewing the neurobiological and socio-affective effects of stress throughout the lifespan
Mañas-Ojeda, Aroa; Ros, Francisco; Olucha-Bordonau, Francisco E; Castillo-Gómez, Esther MDPI (2020-08-13)Social and affective relations occur at every stage of our lives. Impairments in the quality of this “social world” can be exceptionally detrimental and lead to psychopathology or pathological behavior, including ... -
Central relaxin-3 receptor (RXFP3) activation impairs social recognition and modulates ERK-phosphorylation in specific GABAergic amygdala neurons
Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Ma, Sherie; García Díaz, Cristina; Gundlach, Andrew Lawrence; Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E Springer (2019-01)In mammals, the extended amygdala is a neural hub for social and emotional information processing. In the rat, the extended amygdala receives inhibitory GABAergic projections from the nucleus incertus (NI) in the pontine ... -
Central relaxin-3 receptor (RXFP3) activation increases ERK phosphorylation in septal cholinergic neurons and impairs spatial working memory.
Albert Gasco, Hector; García Avilés, Álvaro; Moustafa, S.; Sánchez-Sarasúa, Sandra; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E; Sánchez-Pérez, Ana María Springer (2016-05-05)The medial septum/diagonal band (MS/DB) is a relay region connecting the hypothalamus and brainstem with the hippocampus, and both the MS/DB and dorsal/ventral hippocampus receive strong topographic GABA/peptidergic ... -
Comparative Distribution of Relaxin-3 Inputs and Calcium-Binding Protein-Positive Neurons in Rat Amygdala
Santos, F. N.; Pereira, C. W.; Sánchez-Pérez, Ana María; Otero García, Marcos; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2016)The neural circuits involved in mediating complex behaviors are being rapidly elucidated using various newly developed and powerful anatomical and molecular techniques, providing insights into the neural basis for anxiety ... -
Datasets from: Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization, and septal-gating of temporal lobe theta rhythm activity
Gil-Miravet, Isis; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Ros Bernal, Francisco; Gundlach, Andrew Lawrence; Nuñez Molina, Angel; Olucha-Bordonau, Francisco E (2023) -
Distribution and targets of the relaxin-3 innervation of the septal area in the rat
Sánchez-Pérez, Ana María; Olucha-Bordonau, Francisco E; Otero García, Marcos; Núñez, Ángel; Ma, Sherie; Gundlach, Andrew Lawrence Wiley-Blackwell (2012)Neural tracing studies have revealed that the rat medial and lateral septum are targeted by ascending projections from the nucleus incertus, a population of tegmental GABA neurons. These neurons express the relaxin-family ... -
Efectos del metilfenidato sobre la ansiedad
Sánchez-Pérez, Ana María; García Avilés, Álvaro; Albert Gasco, Hector; Olucha-Bordonau, Francisco E; Sanjuán, Julio (2013-04-15)The attention deficit disorder with hyperactivity (ADDH) is a widely recognized disorder of unknown etiology. Methylphenidate administration is one of the most commonly used treatments to improve symptoms associated with ... -
Electrolytic lesion of the nucleus incertus retards extinction of auditory conditioned fear
Pereira, C. W.; Santos, F. N.; Sánchez-Pérez, Ana María; Otero García, Marcos; Marchioro, M.; Ma, Sherie; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2013-06-15)Fear memory circuits in the brain function to allow animals and humans to recognize putative sources of danger and adopt an appropriate behavioral response; and research on animal models of fear have helped reveal the ... -
From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues
Gil-Miravet, Isis; Melchor Eixea, Ignasi; Arias-Sandoval, Edgar; Vasquez‐Celaya, Lizbeth; Olucha-Bordonau, Francisco E; MIQUEL, MARTA Wiley (2019)It is now increasingly clear that the cerebellum may modulate brain functions altered in drug addiction. We previously demonstrated that cocaine‐induced conditioned preference increased activity at the dorsal posterior ... -
GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
Albert Gasco, Hector; Ma, Sherie; Ros Bernal, Francisco; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2018-01-17)The medial septum (MS) complex modulates hippocampal function and related behaviors. Septohippocampal projections promote and control different forms of hippocampal synchronization. Specifically, GABAergic and cholinergic ... -
Involvement of the Nucleus Incertus and Relaxin-3/RXFP3 Signaling System in Explicit and Implicit Memory
Gil-Miravet, Isis; Mañas-Ojeda, Aroa; Ros Bernal, Francisco; Castillo-Gómez, Esther; Albert Gasco, Hector; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Frontiers Media (2021-03-18)Telencephalic cognitive and emotional circuits/functions are strongly modulated by subcortical inputs. The main focus of past research on the nature of this modulation has been on the widespread monoamine projections to ... -
MAP/ERK Signaling in Developing Cognitive and Emotional Function and Its Effect on Pathological and Neurodegenerative Processes
Albert Gasco, Hector; Ros, Francisco; Castillo-Gómez, Esther; Olucha-Bordonau, Francisco E MDPI (2020-06-23)The signaling pathway of the microtubule-associated protein kinase or extracellular regulated kinase (MAPK/ERK) is a common mechanism of extracellular information transduction from extracellular stimuli to the intracellular ... -
Mapping cFos expression after cerebellar and medial prefrontal deactivations in rats trained to acquire cocaine-induced preference conditioning
Gil-Miravet, Isis; Guarque-Chabrera, Julian; Musoles Lleó, Juan Luis; Olucha-Bordonau, Francisco E; MIQUEL, MARTA Mediterranean Neuroscience Society (2017-06) -
Modulation of forebrain function by nucleus incertus and relaxin-3/RXFP3 signaling
Olucha-Bordonau, Francisco E; Albert Gasco, Hector; Ros Bernal, Francisco; Rytova, Valeria; Ong-Pålsson, Emma K. E.; Ma, Shuai; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence Wiley (2018)The nucleus incertus (NI) in the pontine tegmentum sends ascending projections to the midbrain, hypothalamus, amygdala, basal forebrain, hippocampus, and prefrontal cortex, and has a postulated role in modulating several ... -
Noncovalent Peptide Stapling Using Alpha-Methyl-l-Phenylalanine for α-Helical Peptidomimetics
Bathgate, Ross A. D.; Praveen, Praveen; Sethi, Ashish; Dhingra, Rishi R.; Kocan, Martina; Ou, Qinghao; Valkovic, Adam L.,; Gil-Miravet, Isis; Navarro Sánchez, Mónica; Olucha-Bordonau, Francisco E; Gundlach, Andrew Lawrence; Rosengren, K. Johan; Dutschmann, Mathias; Hossain, Mohammed Akhter American Chemical Society (2023-08-20)Peptides and peptidomimetics are attractive drug candidates because of their high target specificity and low-toxicity profiles. Developing peptidomimetics using hydrocarbon (HC)-stapling or other stapling strategies has ... -
Nucleus incertus ablation disrupted conspecific recognition and modified immediate early gene expression patterns in ‘social brain’ circuits of rats
García Díaz, Cristina; Sánchez-Catalán, María José; Castro-Salazar, E.; García Avilés, Álvaro; Albert Gasco, Hector; Sánchez-Sarasúa, Sandra; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Elsevier (2019-01-01)Social interaction involves neural activity in prefrontal cortex, septum, hippocampus, amygdala and hypothalamus. Notably, these areas all receive projections from the nucleus incertus (NI) in the pontine tegmentum. ... -
Nucleus incertus projections to rat medial septum and entorhinal cortex: rare collateralization and septal-gating of temporal lobe theta rhythm activity
Gil-Miravet, Isis; Nuñez Molina, Angel; Navarro Sánchez, Mónica; Castillo-Gómez, Esther; Ros, Francisco; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E Springer (2023)Nucleus incertus (NI) neurons in the pontine tegmentum give rise to ascending forebrain projections and express the neuropeptide relaxin-3 (RLN3) which acts via the relaxin-family peptide 3 receptor (RXFP3). Activity in ... -
Un nuevo agente en los mecanismos de la adicción al alcohol y la ingesta: el núcleo incertus y el neuropéptido relaxina-3
Nova Marqués, José Antonio; García Díaz, Cristina; Olucha-Bordonau, Francisco E Viguera Editores (2018)La ingesta de alcohol está facilitada por la relación con la conducta alimentaria, y ambas conductas están altamente influidas por situaciones de estrés y ansiedad. La desregulación de estos procesos puede llegar a ...