From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues
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Altres documents de l'autoria: Gil-Miravet, Isis; Melchor Eixea, Ignasi; Arias-Sandoval, Edgar; Vasquez‐Celaya, Lizbeth; Olucha-Bordonau, Francisco E; MIQUEL, MARTA
Metadades
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INVESTIGACIONMetadades
Títol
From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cuesAutoria
Data de publicació
2019Editor
WileyISSN
1355-6215; 1369-1600Cita bibliogràfica
Gil‐Miravet, I, Melchor‐Eixea, I, Arias‐Sandoval, E, et al. From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues. Addiction Biology. 2019; e12834. https://doi.org/10.1111/adb.12834Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://onlinelibrary.wiley.com/doi/full/10.1111/adb.12834Versió
info:eu-repo/semantics/submittedVersionParaules clau / Matèries
Resum
It is now increasingly clear that the cerebellum may modulate brain functions altered in drug addiction. We previously demonstrated that cocaine‐induced conditioned preference increased activity at the dorsal posterior ... [+]
It is now increasingly clear that the cerebellum may modulate brain functions altered in drug addiction. We previously demonstrated that cocaine‐induced conditioned preference increased activity at the dorsal posterior cerebellar vermis. Unexpectedly, a neurotoxic lesion at this region increased the probability of cocaine‐induced conditioned preference acquisition. The present research aimed at providing an explanatory model for such as facilitative effect of the cerebellar lesion. First, we addressed a tracing study in which we found a direct projection from the lateral (dentate) nucleus to the ventral tegmental area (VTA) that also receives Purkinje axons from lobule VIII in the vermis. This pathway might control the activity and plasticity of the cortico‐striatal circuitry. Then we evaluated cFos expression in different regions of the medial prefrontal cortex and striatum after a lesion in lobule VIII before conditioning. Additionally, perineuronal net (PNN) expression was assessed to explore whether the cerebellar lesion might affect synaptic stabilization mechanisms in the medial prefrontal cortex (mPFC). Damage in this region of the vermis induced general disinhibition of the mPFC and striatal subdivisions that receive dopaminergic projections, mainly from the VTA. Moreover, cerebellar impairment induced an upregulation of PNN expression in the mPFC. The major finding of this research was to provide an explanatory model for the function of the posterior cerebellar vermis on drug‐related memory. In this model, damage of the posterior vermis would release striatum‐cortical networks from the inhibitory tonic control exerted by the cerebellar cortex over VTA, thereby promoting drug effects. [-]
Descripció
This is the pre-peer reviewed version of the following article: From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues, which has ... [+]
This is the pre-peer reviewed version of the following article: From back to front: A functional model for the cerebellar modulation in the establishment of conditioned preferences for cocaine‐related cues, which has been published in final form at https://doi.org/10.1111/adb.12834. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. [-]
Publicat a
Addiction Biology. 2019Proyecto de investigación
Consejo Nacional de Ciencia y Tecnología. Grant Number: CONACyT‐ 575913; Plan Nacional de Drogas 2017. Grant Number: PND‐132400; Ministerio de Economía y Competitividad (MINECO). Grant Number: PSI2015‐68600‐P; UJI. Grant Number: 14I307.01/1; Universitat Jaume I. Grant Numbers: 14I307.01/1, PREDOC2014/11; Ministerio de Educación Cultura y Deporte. Grant Number: FPU12/04059Drets d'accés
Copyright © John Wiley & Sons, Inc.
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info:eu-repo/semantics/openAccess
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info:eu-repo/semantics/openAccess
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