GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA
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Otros documentos de la autoría: Albert Gasco, Hector; Ma, Sherie; Ros Bernal, Francisco; Sánchez-Pérez, Ana María; Gundlach, Andrew Lawrence; Olucha-Bordonau, Francisco E
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GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNAAutoría
Fecha de publicación
2018-01-17Editor
Frontiers MediaCita bibliográfica
ALBERT GASCÓ, Héctor; MA, Sherie; ROS BERNAL, Francisco; SÁNCHEZ-PÉREZ, Ana María; GUNDLACH, Andrew L.; OLUCHA BORDONAU, Francisco E. GABAergic Neurons in the Rat Medial Septal Complex Express Relaxin-3 Receptor (RXFP3) mRNA. Frontiers in Neuroanatomy (2018), v. 11Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.frontiersin.org/articles/10.3389/fnana.2017.00133/fullVersión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
The medial septum (MS) complex modulates hippocampal function and related
behaviors. Septohippocampal projections promote and control different forms of
hippocampal synchronization. Specifically, GABAergic and ... [+]
The medial septum (MS) complex modulates hippocampal function and related
behaviors. Septohippocampal projections promote and control different forms of
hippocampal synchronization. Specifically, GABAergic and cholinergic projections
targeting the hippocampal formation from the MS provide bursting discharges to
promote theta rhythm, or tonic activity to promote gamma oscillations. In turn, the
MS is targeted by ascending projections from the hypothalamus and brainstem. One
of these projections arises from the nucleus incertus in the pontine tegmentum,
which contains GABA neurons that co-express the neuropeptide relaxin-3 (Rln3). Both
stimulation of the nucleus incertus and septal infusion of Rln3 receptor agonist peptides
promotes hippocampal theta rhythm. The Gi=o-protein-coupled receptor, relaxin-family
peptide receptor 3 (RXFP3), is the cognate receptor for Rln3 and identification of
the transmitter phenotype of neurons expressing RXFP3 in the septohippocampal
system can provide further insights into the role of Rln3 transmission in the promotion
of septohippocampal theta rhythm. Therefore, we used RNAscope multiplex in situ
hybridization to characterize the septal neurons expressing Rxfp3 mRNA in the rat.
Our results demonstrate that Rxfp3 mRNA is abundantly expressed in vesicular GABA
transporter (vGAT) mRNA- and parvalbumin (PV) mRNA-positive GABA neurons in MS,
whereas ChAT mRNA-positive acetylcholine neurons lack Rxfp3 mRNA. Approximately
75% of Rxfp3 mRNA-positive neurons expressed vGAT mRNA (and 22% were PV
mRNA-positive), while the remaining 25% expressed Rxfp3 mRNA only, consistent with
a potential glutamatergic phenotype. Similar proportions were observed in the posterior
septum. The occurrence of RXFP3 in PV-positive GABAergic neurons gives support to
a role for the Rln3-RXFP3 system in septohippocampal theta rhythm. [-]
Publicado en
Frontiers in Plant Science (2018), v. 11Derechos de acceso
info:eu-repo/semantics/openAccess
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