Listar Departament: Física por autoría "11614e15-6246-49e0-ad9c-86a80376ce62"
Mostrando ítems 1-6 de 6
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Biphasic concentration patterns in ionic transport under nanoconfinement revealed in steady-state and time-dependent properties
Queralt-Martín, María; Perez-Grau, Jose J.; Alvero González, Laidy Maidel; Perini, Deborah Aurora; Cervera, Javier; Aguilella, Vicente; Alcaraz, Antonio American Institute of Physics (2023-02-08)Ion permeation across nanoscopic structures differs considerably from microfluidics because of strong steric constraints, transformed solvent properties, and charge-regulation effects revealed mostly in diluted solutions. ... -
Dynorphin A induces membrane permeabilization by formation of proteolipidic pores. Insights from electrophysiology and computational simulations
Perini, Deborah Aurora; Aguilella-Arzo, Marcel; Alcaraz, Antonio; Perálvarez-Marín, Alex; Queralt-Martín, María Elsevier (2021-12-16)Dynorphins are endogenous neuropeptides that function as ligands for the κ-opioid receptor. In addition to opioid activity, dynorphins can induce several pathological effects such as neurological dysfunctions and cell ... -
Lipid Headgroup Charge and Acyl Chain Composition Modulate Closure of Bacterial β-Barrel Channels
Perini, Deborah Aurora; Alcaraz, Antonio; Queralt-Martín, María MDPI (2019-02)The outer membrane of Gram-negative bacteria contains β-barrel proteins that form high-conducting ion channels providing a path for hydrophilic molecules, including antibiotics. Traditionally, these proteins have been ... -
Probing electrophysiological activity of amphiphilic Dynorphin A in planar neutral membranes reveals both ion channel-like activity and neuropeptide translocation
Alvero González, Laidy Maidel; Perini, Deborah Aurora; Queralt-Martín, María; Peralvarez-Marin, Alex; Viñas, Clara; Alcaraz, Antonio Elsevier (2023-12)Dynorphin A (DynA) is an endogenous neuropeptide that besides acting as a ligand of the κ-opioid receptor, presents some non-opioid pathophysiological properties associated to its ability to induce cell permeability similarly ... -
Specific adsorption of trivalent cations in biological nanopores determines conductance dynamics and reverses ionic selectivity
Queralt-Martín, María; Perini, Deborah Aurora; Alcaraz, Antonio Royal Society of Chemistry (2020-12-11)Adsorption processes are central to ionic transport in industrial and biological membrane systems. Multivalent cations modulate the conductive properties of nanofluidic devices through interactions with charged surfaces ... -
Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer Integrity
Perini, Deborah Aurora; Parra-Ortiz, Elisa; Varó, Inmaculada; Queralt-Martín, María; Malmsten, Martin; Alcaraz, Antonio ACS Publications (2022)Although nanoplastics have well-known toxic effects toward the environment and living organisms, their molecular toxicity mechanisms, including the nature of nanoparticle−cell membrane interactions, are still under ...