Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer Integrity
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Mostrar el registro completo del ítemcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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Título
Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer IntegrityAutoría
Fecha de publicación
2022Editor
ACS PublicationsCita bibliográfica
Langmuir 2022, 38, 14837−14849Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://pubs.acs.org/doi/full/10.1021/acs.langmuir.2c02487Versión
info:eu-repo/semantics/publishedVersionResumen
Although nanoplastics have well-known toxic effects toward the environment and living organisms, their molecular
toxicity mechanisms, including the nature of nanoparticle−cell membrane interactions, are still under ... [+]
Although nanoplastics have well-known toxic effects toward the environment and living organisms, their molecular
toxicity mechanisms, including the nature of nanoparticle−cell membrane interactions, are still under investigation. Here, we employ
dynamic light scattering, quartz crystal microbalance with dissipation monitoring, and electrophysiology to investigate the interaction
between polystyrene nanoparticles (PS NPs) and phospholipid membranes. Our results show that PS NPs adsorb onto lipid bilayers
creating soft inhomogeneous films that include disordered defects. PS NPs form an integral part of the generated channels so that
the surface functionalization and charge of the NP determine the pore conductive properties. The large difference in size between
the NP diameter and the lipid bilayer thickness (∼60 vs ∼5 nm) suggests a particular and complex lipid−NP assembly that is able to
maintain overall membrane integrity. In view of this, we suggest that NP-induced toxicity in cells could operate in more subtle ways
than membrane disintegration, such as inducing lipid reorganization and transmembrane ionic fluxes that disrupt the membrane
potential. [-]
Publicado en
Langmuir 2022, 38, 48.Entidad financiadora
Agencia Estatal de Investigación | Universitat Jaume I | Generalitat Valenciana | Swedish Research Council | Independent Research Fund Denmark | LEO Foundation Center for Cutaneous Drug Delivery
Código del proyecto o subvención
2019-108434GB-I00 | IJC2018-035283-I | UJI-B2018-53 | UJI-A2020- 21 | GRISOLIAP/2018/061 | AICO/ 2020/066 | BEFPI/2020/040 | 2016-05157 | 2021-05498 | 9040-00020B | 2016-11-01
Derechos de acceso
Copyright © 2022 American Chemical Society
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
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