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Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
dc.contributor.author | Nakken, Charlotte Langeland | |
dc.contributor.author | Meier, Sonnich | |
dc.contributor.author | Mjøs, Svein Are | |
dc.contributor.author | Bijlsma, Lubertus | |
dc.contributor.author | Rowland, Steven | |
dc.contributor.author | Donald, Carey | |
dc.date.accessioned | 2024-02-20T19:14:41Z | |
dc.date.available | 2024-02-20T19:14:41Z | |
dc.date.issued | 2024 | |
dc.identifier.citation | NAKKEN, Charlotte L., et al. Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1, 4-dimethylphenanthrene. Science of The Total Environment, 2024, 170496 | ca_CA |
dc.identifier.issn | 1879-1026 | |
dc.identifier.issn | 0048-9697 | |
dc.identifier.uri | http://hdl.handle.net/10234/205955 | |
dc.description.abstract | Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated in oil-exposed fish. Should these compounds be discovered in fish as they have in ragworm, rodents, and humans, they could present an indicative biomarker for assessing oil pollution. In this study, the ability to biotransform alkyl PAHs to PAAs was examined on Atlantic haddock (Melanogrammus aeglefinus). Exposure to phenanthrene, 1-methyphenanthrene or 1,4-dimethylphenanthrene was performed via intraperitoneal injection. An Ion Mobility Quadrupole Time-Of-Flight Mass Spectrometer (IMS-Q-TOF MS) was used in exploratory analysis of extracted bile samples. Acquisition of four-dimensional information by coupling liquid chromatography with the IMS-Q-TOF MS and in-silico prediction for feature prioritization in the data processing workflow allowed several tentative identifications with high degree of confidence. This work presents the first detection of PAAs in fish and suggests the importance of investigating alkyl PAHs in ecotoxicological studies of oil-polluted fish environments. | ca_CA |
dc.format.extent | 6 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation.isPartOf | Science of The Total Environment, 2024, 170496 | ca_CA |
dc.rights | © 2024 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | Alkylated polycyclic aromatic hydrocarbons (alkyl PAHs) | ca_CA |
dc.subject | Atlantic haddock | ca_CA |
dc.subject | Bile metabolites | ca_CA |
dc.subject | Environmental monitoring | ca_CA |
dc.subject | Suspect screening | ca_CA |
dc.subject | In-silico predictions | ca_CA |
dc.title | Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.scitotenv.2024.170496 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MICIN/AEI/10.13039/501100011033 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S0048969724006338 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.name | Norwegian State Pollution Control Agency | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Universitat Jaume I | ca_CA |
project.funder.name | Equinor ASA | ca_CA |
oaire.awardNumber | RYC2020-028936-I | ca_CA |
oaire.awardNumber | UJI-B2022-16 | ca_CA |
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