Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
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INVESTIGACIONMetadades
Títol
Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthreneAutoria
Data de publicació
2024Editor
ElsevierISSN
1879-1026; 0048-9697Cita bibliogràfica
NAKKEN, Charlotte L., et al. Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1, 4-dimethylphenanthrene. Science of The Total Environment, 2024, 170496Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.sciencedirect.com/science/article/pii/S0048969724006338Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be ... [+]
Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated in oil-exposed fish. Should these compounds be discovered in fish as they have in ragworm, rodents, and humans, they could present an indicative biomarker for assessing oil pollution. In this study, the ability to biotransform alkyl PAHs to PAAs was examined on Atlantic haddock (Melanogrammus aeglefinus). Exposure to phenanthrene, 1-methyphenanthrene or 1,4-dimethylphenanthrene was performed via intraperitoneal injection. An Ion Mobility Quadrupole Time-Of-Flight Mass Spectrometer (IMS-Q-TOF MS) was used in exploratory analysis of extracted bile samples. Acquisition of four-dimensional information by coupling liquid chromatography with the IMS-Q-TOF MS and in-silico prediction for feature prioritization in the data processing workflow allowed several tentative identifications with high degree of confidence. This work presents the first detection of PAAs in fish and suggests the importance of investigating alkyl PAHs in ecotoxicological studies of oil-polluted fish environments. [-]
Publicat a
Science of The Total Environment, 2024, 170496Entitat finançadora
Norwegian State Pollution Control Agency | Ministerio de Ciencia, Innovación y Universidades | Universitat Jaume I | Equinor ASA
Codi del projecte o subvenció
RYC2020-028936-I | UJI-B2022-16
Proyecto de investigación
info:eu-repo/grantAgreement/MICIN/AEI/10.13039/501100011033Drets d'accés
info:eu-repo/semantics/openAccess
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