Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthrene
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Título
Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1,4-dimethylphenanthreneAutoría
Fecha de publicación
2024Editor
ElsevierISSN
1879-1026; 0048-9697Cita bibliográfica
NAKKEN, Charlotte L., et al. Discovery of polycyclic aromatic acid metabolites in fish exposed to the petroleum compounds 1-methylphenanthrene and 1, 4-dimethylphenanthrene. Science of The Total Environment, 2024, 170496Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://www.sciencedirect.com/science/article/pii/S0048969724006338Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be ... [+]
Most of the polycyclic aromatic hydrocarbons (PAHs) in petroleum are alkylated (alkyl PAHs), still the metabolism of these alkyl PAHs to the expected acid products (polycyclic aromatic acids; PAAs) has yet to be demonstrated in oil-exposed fish. Should these compounds be discovered in fish as they have in ragworm, rodents, and humans, they could present an indicative biomarker for assessing oil pollution. In this study, the ability to biotransform alkyl PAHs to PAAs was examined on Atlantic haddock (Melanogrammus aeglefinus). Exposure to phenanthrene, 1-methyphenanthrene or 1,4-dimethylphenanthrene was performed via intraperitoneal injection. An Ion Mobility Quadrupole Time-Of-Flight Mass Spectrometer (IMS-Q-TOF MS) was used in exploratory analysis of extracted bile samples. Acquisition of four-dimensional information by coupling liquid chromatography with the IMS-Q-TOF MS and in-silico prediction for feature prioritization in the data processing workflow allowed several tentative identifications with high degree of confidence. This work presents the first detection of PAAs in fish and suggests the importance of investigating alkyl PAHs in ecotoxicological studies of oil-polluted fish environments. [-]
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Science of The Total Environment, 2024, 170496Entidad financiadora
Norwegian State Pollution Control Agency | Ministerio de Ciencia, Innovación y Universidades | Universitat Jaume I | Equinor ASA
Código del proyecto o subvención
RYC2020-028936-I | UJI-B2022-16
Proyecto de investigación
info:eu-repo/grantAgreement/MICIN/AEI/10.13039/501100011033Derechos de acceso
info:eu-repo/semantics/openAccess
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