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Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
dc.contributor.author | Gallego Villarejo, Lucia | |
dc.contributor.author | Wallin, Cecilia | |
dc.contributor.author | Król, Sylwia | |
dc.contributor.author | Enrich Bengoa, Jennifer | |
dc.contributor.author | Suades, Albert | |
dc.contributor.author | Aguilella-Arzo, Marcel | |
dc.contributor.author | Gómara Elena, María José | |
dc.contributor.author | Haro, Isabel | |
dc.contributor.author | Wärmlander, Sebastian | |
dc.contributor.author | Muñoz, Francisco J. | |
dc.contributor.author | Gräslund, Astrid | |
dc.contributor.author | Perálvarez-Marín, Alex | |
dc.date.accessioned | 2023-04-20T07:52:35Z | |
dc.date.available | 2023-04-20T07:52:35Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | Gallego-Villarejo L, Wallin C, Król S, Enrich-Bengoa J, Suades A, Aguilella-Arzo M, Gomara MJ, Haro I, Wärmlander S, Muñoz FJ, Gräslund A, Perálvarez-Marín A. Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity. Comput Struct Biotechnol J. 2022 Oct 14;20:5672-9. DOI: 10.1016/j.csbj.2022.10.014 | ca_CA |
dc.identifier.issn | 2001-0370 | |
dc.identifier.uri | http://hdl.handle.net/10234/202222 | |
dc.description.abstract | Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid neuropeptides, with Aβ40 the most abundant species of Aβ. Biophysical measurements indicate that Aβ40 interacts with Big Dynorphin (BigDyn), lowering the amount of hydrophobic aggregates, and slowing down the aggregation kinetics. As expected, we found that BigDyn protects against Aβ40 aggregates when studied in human neuroblastoma cells by cell survival assays. The cross-interaction between BigDyn and Aβ40 provides insight into the mechanism of amyloid pathophysiology and may open up new therapy possibilities. | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Elsevier | ca_CA |
dc.relation | Estudio biofísico de los mecanismos de permeabilización de membranas inducidos por canales iónicos | ca_CA |
dc.relation | Determinantes moleculares en canales iónicos: desde formación de poros a identificación de fármacos basada en ligandos | ca_CA |
dc.relation.isPartOf | Computational and structural biotechnology journal, 2022, vol. 20 | ca_CA |
dc.rights | © 2022 Published by Elsevier B.V. on behalf of Research Network of Computational and Structural Biotechnology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | ca_CA |
dc.subject | Alzheimer’s disease | ca_CA |
dc.subject | amyloid β-peptide | ca_CA |
dc.subject | dynorphins | ca_CA |
dc.subject | peptide therapy | ca_CA |
dc.subject | biophysics | ca_CA |
dc.title | Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1016/j.csbj.2022.10.014 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.sciencedirect.com/science/article/pii/S2001037022004615?via%3Dihub | ca_CA |
dc.description.sponsorship | This work was supported by the Spanish Ministry of Science and Innovation and Agencia Estatal de Investigación through grant MCIN/AEI/ https://doi.org/10.13039/501100011033 (projects 2019-108434GB-I00 to M.A.-A., PID2020-117691RB-I00 to F.J.M., and PID2020-120222GB-I00 to A.P.-M.), Generalitat Valenciana (project AICO/2020/066 to M.A-A.), FEDER Funds and by the “María de Maeztu Programme” for Units of Excellence in R&D (award CEX2018-000792-M). A.G. was supported by grants from the Swedish Research Council. | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.identifier | http://dx.doi.org/10.13039/501100011033 | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
project.funder.name | Generalitat Valenciana | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/PID2019-108434GB-I00 | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/PID2020-120222GB-I00 | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/PID2020-117691RB-I00 | ca_CA |
oaire.awardNumber | AICO/2020/066 | ca_CA |
oaire.awardNumber | CEX2018-000792-M | ca_CA |
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