Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
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Show full item recordcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
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INVESTIGACIONMetadata
Title
Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicityAuthor (s)
Date
2022Publisher
ElsevierISSN
2001-0370Bibliographic citation
Gallego-Villarejo L, Wallin C, Król S, Enrich-Bengoa J, Suades A, Aguilella-Arzo M, Gomara MJ, Haro I, Wärmlander S, Muñoz FJ, Gräslund A, Perálvarez-Marín A. Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity. Comput Struct Biotechnol J. 2022 Oct 14;20:5672-9. DOI: 10.1016/j.csbj.2022.10.014Type
info:eu-repo/semantics/articleVersion
info:eu-repo/semantics/publishedVersionSubject
Abstract
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments ... [+]
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid neuropeptides, with Aβ40 the most abundant species of Aβ. Biophysical measurements indicate that Aβ40 interacts with Big Dynorphin (BigDyn), lowering the amount of hydrophobic aggregates, and slowing down the aggregation kinetics. As expected, we found that BigDyn protects against Aβ40 aggregates when studied in human neuroblastoma cells by cell survival assays. The cross-interaction between BigDyn and Aβ40 provides insight into the mechanism of amyloid pathophysiology and may open up new therapy possibilities. [-]
Is part of
Computational and structural biotechnology journal, 2022, vol. 20Funder Name
Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana
Funder ID
http://dx.doi.org/10.13039/501100011033
Project code
MICIU/ICTI2017-2020/PID2019-108434GB-I00 | MICIU/ICTI2017-2020/PID2020-120222GB-I00 | MICIU/ICTI2017-2020/PID2020-117691RB-I00 | AICO/2020/066 | CEX2018-000792-M
Project title or grant
Estudio biofísico de los mecanismos de permeabilización de membranas inducidos por canales iónicos | Determinantes moleculares en canales iónicos: desde formación de poros a identificación de fármacos basada en ligandos
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info:eu-repo/semantics/openAccess
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