Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
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comunitat-uji-handle3:10234/6973
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INVESTIGACIONMetadades
Títol
Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicityAutoria
Data de publicació
2022Editor
ElsevierISSN
2001-0370Cita bibliogràfica
Gallego-Villarejo L, Wallin C, Król S, Enrich-Bengoa J, Suades A, Aguilella-Arzo M, Gomara MJ, Haro I, Wärmlander S, Muñoz FJ, Gräslund A, Perálvarez-Marín A. Big dynorphin is a neuroprotector scaffold against amyloid β-peptide aggregation and cell toxicity. Comput Struct Biotechnol J. 2022 Oct 14;20:5672-9. DOI: 10.1016/j.csbj.2022.10.014Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.sciencedirect.com/science/article/pii/S2001037022004615?via%3DihubVersió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments ... [+]
Amyloid β-peptide (Aβ) misfolding into β-sheet structures triggers neurotoxicity inducing Alzheimer’s disease (AD). Molecules able to reduce or to impair Aβ aggregation are highly relevant as possible AD treatments since they should protect against Aβ neurotoxicity. We have studied the effects of the interaction of dynorphins, a family of opioid neuropeptides, with Aβ40 the most abundant species of Aβ. Biophysical measurements indicate that Aβ40 interacts with Big Dynorphin (BigDyn), lowering the amount of hydrophobic aggregates, and slowing down the aggregation kinetics. As expected, we found that BigDyn protects against Aβ40 aggregates when studied in human neuroblastoma cells by cell survival assays. The cross-interaction between BigDyn and Aβ40 provides insight into the mechanism of amyloid pathophysiology and may open up new therapy possibilities. [-]
Publicat a
Computational and structural biotechnology journal, 2022, vol. 20Entitat finançadora
Ministerio de Ciencia, Innovación y Universidades | Generalitat Valenciana
Identificador de l'entitat finançadora
http://dx.doi.org/10.13039/501100011033
Codi del projecte o subvenció
MICIU/ICTI2017-2020/PID2019-108434GB-I00 | MICIU/ICTI2017-2020/PID2020-120222GB-I00 | MICIU/ICTI2017-2020/PID2020-117691RB-I00 | AICO/2020/066 | CEX2018-000792-M
Títol del projecte o subvenció
Estudio biofísico de los mecanismos de permeabilización de membranas inducidos por canales iónicos | Determinantes moleculares en canales iónicos: desde formación de poros a identificación de fármacos basada en ligandos
Drets d'accés
info:eu-repo/semantics/openAccess
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