Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration
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Altres documents de l'autoria: Rodríguez Doblado, Laura; Martínez Ramos, Cristina; Monleón Pradas, Manuel
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/36080
comunitat-uji-handle3:10234/36082
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INVESTIGACIONMetadades
Títol
Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal RegenerationData de publicació
2022-09Editor
MDPIISSN
2227-9059Cita bibliogràfica
Rodríguez Doblado, L.; Martínez-Ramos, C.; Monleón Pradas, M. Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration. Biomedicines 2022, 10, 2228. https://doi.org/10.3390/biomedicines10092228Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://www.mdpi.com/2227-9059/10/9/2228Versió
info:eu-repo/semantics/publishedVersionParaules clau / Matèries
Resum
Axonal bundles or axonal tracts have an aligned and unidirectional architecture present in many neural structures with different lengths. When peripheral nerve injury (PNI), spinal cord injury (SCI), traumatic brain ... [+]
Axonal bundles or axonal tracts have an aligned and unidirectional architecture present in many neural structures with different lengths. When peripheral nerve injury (PNI), spinal cord injury (SCI), traumatic brain injury (TBI), or neurodegenerative disease occur, the intricate architecture undergoes alterations leading to growth inhibition and loss of guidance through large distance. In order to overcome the limitations of long-distance axonal regeneration, here we combine a poly-L-lactide acid (PLA) fiber bundle in the common lumen of a sequence of hyaluronic acid (HA) conduits or modules and pre-cultured Schwann cells (SC) as cells supportive of axon extension. This multimodular preseeded conduit is then used to induce axon growth from a dorsal root ganglion (DRG) explant placed at one of its ends and left for 21 days to follow axon outgrowth. The multimodular conduit proved effective in promoting directed axon growth, and the results may thus be of interest for the regeneration of long tissue defects in the nervous system. Furthermore, the hybrid structure grown within the HA modules consisting in the PLA fibers and the SC can be extracted from the conduit and cultured independently. This “neural cord” proved to be viable outside its scaffold and opens the door to the generation of ex vivo living nerve in vitro for transplantation. [-]
Publicat a
Biomedicines 2022, vol. 10, no 9Entitat finançadora
Ministerio de Educación, Cultura y Deporte | Ministerio de Economía y Competitividad | Ministerio de Ciencia, Innovación y Universidades
Identificador de l'entitat finançadora
http://dx.doi.org/10.13039/501100003176 | http://dx.doi.org/10.13039/501100011033 | ttp://dx.doi.org/10.13039/501100003329
Codi del projecte o subvenció
FPU15/04975 | MINECO//DPI2015-72863-EXP | MICIU/ICTI2017-2020/RTI2018-095872-B-C22
Títol del projecte o subvenció
Neurocables Modulares: multiplicando conexiones neurales | Nuevo dispositivo bioactivo para la regeneración de lesiones de la medula espinal
Drets d'accés
info:eu-repo/semantics/openAccess
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- MED_Articles [662]