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Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration
dc.contributor.author | Rodríguez Doblado, Laura | |
dc.contributor.author | Martínez Ramos, Cristina | |
dc.contributor.author | Monleón Pradas, Manuel | |
dc.date.accessioned | 2023-04-19T06:55:53Z | |
dc.date.available | 2023-04-19T06:55:53Z | |
dc.date.issued | 2022-09 | |
dc.identifier.citation | Rodríguez Doblado, L.; Martínez-Ramos, C.; Monleón Pradas, M. Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration. Biomedicines 2022, 10, 2228. https://doi.org/10.3390/biomedicines10092228 | ca_CA |
dc.identifier.issn | 2227-9059 | |
dc.identifier.uri | http://hdl.handle.net/10234/202196 | |
dc.description.abstract | Axonal bundles or axonal tracts have an aligned and unidirectional architecture present in many neural structures with different lengths. When peripheral nerve injury (PNI), spinal cord injury (SCI), traumatic brain injury (TBI), or neurodegenerative disease occur, the intricate architecture undergoes alterations leading to growth inhibition and loss of guidance through large distance. In order to overcome the limitations of long-distance axonal regeneration, here we combine a poly-L-lactide acid (PLA) fiber bundle in the common lumen of a sequence of hyaluronic acid (HA) conduits or modules and pre-cultured Schwann cells (SC) as cells supportive of axon extension. This multimodular preseeded conduit is then used to induce axon growth from a dorsal root ganglion (DRG) explant placed at one of its ends and left for 21 days to follow axon outgrowth. The multimodular conduit proved effective in promoting directed axon growth, and the results may thus be of interest for the regeneration of long tissue defects in the nervous system. Furthermore, the hybrid structure grown within the HA modules consisting in the PLA fibers and the SC can be extracted from the conduit and cultured independently. This “neural cord” proved to be viable outside its scaffold and opens the door to the generation of ex vivo living nerve in vitro for transplantation. | ca_CA |
dc.format.extent | 16 p. | ca_CA |
dc.format.mimetype | application/pdf | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | MDPI | ca_CA |
dc.relation | Neurocables Modulares: multiplicando conexiones neurales | ca_CA |
dc.relation | Nuevo dispositivo bioactivo para la regeneración de lesiones de la medula espinal | ca_CA |
dc.relation.isPartOf | Biomedicines 2022, vol. 10, no 9 | ca_CA |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | ca_CA |
dc.subject | long-distance axonal regeneration | ca_CA |
dc.subject | hyaluronic acid conduit | ca_CA |
dc.subject | poly-lactic fibers | ca_CA |
dc.subject | dorsal root ganglion culture | ca_CA |
dc.subject | Schwann cell culture | ca_CA |
dc.subject | neural cord | ca_CA |
dc.title | Multimodular Bio-Inspired Organized Structures Guiding Long-Distance Axonal Regeneration | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.3390/biomedicines10092228 | |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | ca_CA |
dc.relation.publisherVersion | https://www.mdpi.com/2227-9059/10/9/2228 | ca_CA |
dc.description.sponsorship | This research was funded by the Spanish Government’s State Research Agency (AEI) through projects DPI2015-72863-EXP and RTI2018-095872-B-C22/ERDF. Laura Rodríguez Doblado acknowledges scholarship FPU15/04975 of the Spanish Ministry of Education, Culture, and Sports. | |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
project.funder.identifier | http://dx.doi.org/10.13039/501100003176 | ca_CA |
project.funder.identifier | http://dx.doi.org/10.13039/501100011033 | |
project.funder.identifier | ttp://dx.doi.org/10.13039/501100003329 | |
project.funder.name | Ministerio de Educación, Cultura y Deporte | ca_CA |
project.funder.name | Ministerio de Economía y Competitividad | ca_CA |
project.funder.name | Ministerio de Ciencia, Innovación y Universidades | ca_CA |
oaire.awardNumber | FPU15/04975 | ca_CA |
oaire.awardNumber | MINECO//DPI2015-72863-EXP | ca_CA |
oaire.awardNumber | MICIU/ICTI2017-2020/RTI2018-095872-B-C22 | ca_CA |
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