Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer Integrity
![Thumbnail](/xmlui/bitstream/handle/10234/202177/84738.pdf.jpg?sequence=4&isAllowed=y)
Visualitza/
Impacte
![Google Scholar](/xmlui/themes/Mirage2/images/uji/logo_google.png)
![Microsoft Academico](/xmlui/themes/Mirage2/images/uji/logo_microsoft.png)
Metadades
Mostra el registre complet de l'elementcomunitat-uji-handle:10234/9
comunitat-uji-handle2:10234/2507
comunitat-uji-handle3:10234/6973
comunitat-uji-handle4:
INVESTIGACIONMetadades
Títol
Surface-Functionalized Polystyrene Nanoparticles Alter the Transmembrane Potential via Ion-Selective Pores Maintaining Global Bilayer IntegrityAutoria
Data de publicació
2022Editor
ACS PublicationsCita bibliogràfica
Langmuir 2022, 38, 14837−14849Tipus de document
info:eu-repo/semantics/articleVersió de l'editorial
https://pubs.acs.org/doi/full/10.1021/acs.langmuir.2c02487Versió
info:eu-repo/semantics/publishedVersionResum
Although nanoplastics have well-known toxic effects toward the environment and living organisms, their molecular
toxicity mechanisms, including the nature of nanoparticle−cell membrane interactions, are still under ... [+]
Although nanoplastics have well-known toxic effects toward the environment and living organisms, their molecular
toxicity mechanisms, including the nature of nanoparticle−cell membrane interactions, are still under investigation. Here, we employ
dynamic light scattering, quartz crystal microbalance with dissipation monitoring, and electrophysiology to investigate the interaction
between polystyrene nanoparticles (PS NPs) and phospholipid membranes. Our results show that PS NPs adsorb onto lipid bilayers
creating soft inhomogeneous films that include disordered defects. PS NPs form an integral part of the generated channels so that
the surface functionalization and charge of the NP determine the pore conductive properties. The large difference in size between
the NP diameter and the lipid bilayer thickness (∼60 vs ∼5 nm) suggests a particular and complex lipid−NP assembly that is able to
maintain overall membrane integrity. In view of this, we suggest that NP-induced toxicity in cells could operate in more subtle ways
than membrane disintegration, such as inducing lipid reorganization and transmembrane ionic fluxes that disrupt the membrane
potential. [-]
Publicat a
Langmuir 2022, 38, 48.Entitat finançadora
Agencia Estatal de Investigación | Universitat Jaume I | Generalitat Valenciana | Swedish Research Council | Independent Research Fund Denmark | LEO Foundation Center for Cutaneous Drug Delivery
Codi del projecte o subvenció
2019-108434GB-I00 | IJC2018-035283-I | UJI-B2018-53 | UJI-A2020- 21 | GRISOLIAP/2018/061 | AICO/ 2020/066 | BEFPI/2020/040 | 2016-05157 | 2021-05498 | 9040-00020B | 2016-11-01
Drets d'accés
Copyright © 2022 American Chemical Society
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Apareix a les col.leccions
- FCA_Articles [511]