Fibrillar networks encapsulated in polymersomes for drug delivery: synthesis of supramolecular gelators and preliminary studies

Abstract

The importance of drug delivery has increased during last years to get the enhancement of the pharmaceutical compounds release in a controlled and a targeted way. To achieve this goal, hydrogels and nanoparticles, polymersomes for instance, are being investigated since last decades. The main objective of the project is the synthesis of polymersomes loaded with a gelator (ImVal8), which forms a fibrillar network at neutral pH, and charged with a drug (naproxen) for its controlled release. This TFG work takes part into this project. Concretely, in this TFG, two gelators were synthesised, ImVal8 and ImValPy, which are going to be used to form the fibrillar network inside polymersomes. In addition, calibrates at different pH to detect the quantity of naproxen released in the medium were carried out.