Fibrillar networks encapsulated in polymersomes for drug delivery: synthesis of supramolecular gelators and preliminary studies
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Mostra el registre complet de l'elementcomunitat-uji-handle:10234/158176
comunitat-uji-handle2:10234/71324
comunitat-uji-handle3:10234/98504
comunitat-uji-handle4:
TFG-TFMAquest recurs és restringit
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Fibrillar networks encapsulated in polymersomes for drug delivery: synthesis of supramolecular gelators and preliminary studiesAutoria
Tutor/Supervisor; Universitat.Departament
Escuder, Beatriu; Universitat Jaume I. Departament de Química Inorgànica i Orgànica; Sancho Llopis, Juan Vicente; Universitat Jaume I. Departament de Química Física i AnalíticaData de publicació
2020-07-10Editor
Universitat Jaume IResum
The importance of drug delivery has increased during last years to get the
enhancement of the pharmaceutical compounds release in a controlled and a
targeted way. To achieve this goal, hydrogels and nanoparticles, ... [+]
The importance of drug delivery has increased during last years to get the
enhancement of the pharmaceutical compounds release in a controlled and a
targeted way. To achieve this goal, hydrogels and nanoparticles, polymersomes
for instance, are being investigated since last decades. The main objective of
the project is the synthesis of polymersomes loaded with a gelator (ImVal8),
which forms a fibrillar network at neutral pH, and charged with a drug
(naproxen) for its controlled release. This TFG work takes part into this project.
Concretely, in this TFG, two gelators were synthesised, ImVal8 and ImValPy,
which are going to be used to form the fibrillar network inside polymersomes. In
addition, calibrates at different pH to detect the quantity of naproxen released in
the medium were carried out. [-]
Paraules clau / Matèries
Descripció
Treball Final de Grau en Química. Codi: QU0943. Curs acadèmic: 2019/2020
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- Grau en Química [265]