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Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3
dc.contributor.author | Sanchez-Andres, Juan V. | |
dc.contributor.author | Malaisse, Willy J. | |
dc.contributor.author | Kojima, Itaru | |
dc.date.accessioned | 2019-02-27T13:23:23Z | |
dc.date.available | 2019-02-27T13:23:23Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Sanchez-Andres, J.V., Malaisse, W.J. & Kojima, I. Pflugers Arch - Eur J Physiol (2018). https://doi.org/10.1007/s00424-018-2237-6 | ca_CA |
dc.identifier.issn | 0031-6768 | |
dc.identifier.issn | 1432-2013 | |
dc.identifier.uri | http://hdl.handle.net/10234/181586 | |
dc.description.abstract | Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of D-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. In this respect, sucralose was inefficient in the absence of D-glucose, but induced on occasion electrical activity in mouse β-cells exposed to low nonstimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of D-glucose. These data indicate that sucralose, acting as an agonist of the TIR3 receptor, exerts an excitatory effect upon pancreatic β-cell bioelectrical activity | ca_CA |
dc.format.extent | 8 p. | ca_CA |
dc.language.iso | eng | ca_CA |
dc.publisher | Springer | ca_CA |
dc.relation.isPartOf | Pflügers Archiv - European Journal of Physiology, 14 December 2018 | ca_CA |
dc.rights | © Springer-Verlag GmbH Germany, part of Springer Nature 2018 | ca_CA |
dc.rights.uri | http://rightsstatements.org/vocab/InC/1.0/ | * |
dc.subject | Bioelectrical activity | ca_CA |
dc.subject | Pancreatic islet β-cells | ca_CA |
dc.subject | Sweet taste receptor TIR3 | ca_CA |
dc.subject | Sucralose | ca_CA |
dc.title | Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3 | ca_CA |
dc.type | info:eu-repo/semantics/article | ca_CA |
dc.identifier.doi | https://doi.org/10.1007/s00424-018-2237-6 | |
dc.rights.accessRights | info:eu-repo/semantics/restrictedAccess | ca_CA |
dc.relation.publisherVersion | https://link.springer.com/article/10.1007/s00424-018-2237-6 | ca_CA |
dc.type.version | info:eu-repo/semantics/publishedVersion | ca_CA |
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