Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3
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Otros documentos de la autoría: Sanchez-Andres, Juan V.; Malaisse, Willy J.; Kojima, Itaru
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https://doi.org/10.1007/s00424-018-2237-6 |
Metadatos
Título
Electrophysiology of the pancreatic islet β-cell sweet taste receptor TIR3Fecha de publicación
2018Editor
SpringerISSN
0031-6768; 1432-2013Cita bibliográfica
Sanchez-Andres, J.V., Malaisse, W.J. & Kojima, I. Pflugers Arch - Eur J Physiol (2018). https://doi.org/10.1007/s00424-018-2237-6Tipo de documento
info:eu-repo/semantics/articleVersión de la editorial
https://link.springer.com/article/10.1007/s00424-018-2237-6Versión
info:eu-repo/semantics/publishedVersionPalabras clave / Materias
Resumen
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells
was documented. The activation of this receptor by sweet-tasting sucralose mimics several ... [+]
Over recent years, the presence of the sweet taste receptor TIR3 in rodent and human insulin-producing pancreatic islet β-cells
was documented. The activation of this receptor by sweet-tasting sucralose mimics several biochemical and functional effects of
D-glucose in the β-cells. The present study extends this analogy to the bioelectrical response of β-cells. In this respect, sucralose
was inefficient in the absence of D-glucose, but induced on occasion electrical activity in mouse β-cells exposed to low nonstimulatory concentrations of the hexose and potentiated, in a concentration-related manner, the response to stimulatory concentrations of D-glucose. These data indicate that sucralose, acting as an agonist of the TIR3 receptor, exerts an excitatory effect upon
pancreatic β-cell bioelectrical activity [-]
Publicado en
Pflügers Archiv - European Journal of Physiology, 14 December 2018Derechos de acceso
© Springer-Verlag GmbH Germany, part of Springer Nature 2018
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